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實(shí)驗(yàn)流程：

單核細(xì)胞蛋白5抗體費(fèi)用 英文名稱  Anti-SAMHD1/HDDC1/MOP5

中文名稱  單核細(xì)胞蛋白5抗體費(fèi)用 

別    名 DCIP; Dendritic cell derived IFNG induced protein; Dendritic cell-derived IFNG-induced protein; HD domain containing 1; HDDC1; Mg11; Monocyte protein 5; MOP 5; MOP5; OTTHUMP00000030889; SAM domain and HD domain 1; SAM domain and HD domain containing protein 1; SAM domain and HD domain-containing protein 1; SAMH1_HUMAN; Samhd1; SBBI88.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Cow, Horse, Zebrafish, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域    細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)菌及

蛋白分子量  predicted molecular weight: 72kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SAMHD1/HDDC1/MOP5

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

單核細(xì)胞蛋白5抗體費(fèi)用 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.

Tissue specificity: Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.

Involvement in disease:

Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) . A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.

Function : Putative nuclease involved in innate immune response byacting as a negative regulator of the cell-intrinsic antiviralresponse. May play a role in mediating proinflammatory responses toTNF-alpha signaling.

Subcellular Location : Nucleus.

Tissue Specificity : Expressed in heart, skeletal muscle, spleen,liver, small intestine, placenta, lung and peripheral bloodleukocytes. No expression is seen in brain and thymus.

DISEASE : Defects in SAMHD1 are the cause of Aicardi-Goutieressyndrome type 5 (AGS5) [MIM:612952]. A form of Aicardi-Goutieressyndrome, a genetically heterogeneous disease characterized bycerebral atrophy, leukoencephalopathy, intracranial calcifications,chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSFalpha-interferon, and negative serologic investigations for commonprenatal infection. Clinical features as thrombocytopenia,hepatosplenomegaly and elevated hepatic transaminases along withintermittent fever may erroneously suggest an infective process.Severe neurological dysfunctions manifest in infancy as progressivemicrocephaly, spasticity, dystonic posturing and profoundpsychomotor retardation. Death often occurs in early childhood.

Defects in SAMHD1 are the cause of chilblain lupus type 2(CHBL2) [MIM:614415]. A rare cutaneous form of lupus erythematosus.Affected individuals present with painful bluish-red papular ornodular lesions of the skin in acral locations precipitated by coldand wet exposure at temperatures less than 10 degrees centigrade.

Similarity : Belongs to the SAMHD1 family.

Contains 1 HD domain.

Contains 1 SAM (sterile alpha motif) domain.

Database links : UniProtKB/Swiss-Prot: Q9Y3Z3.2

近來經(jīng)科學(xué)家研究發(fā)現(xiàn)，SAMHD1蛋白有抑制骨髓細(xì)胞感染（）的機(jī)制，SAMHD1蛋白能感應(yīng)到諸如巨噬細(xì)胞和樹狀細(xì)胞等骨髓細(xì)胞感染到-1（分為1型和2型，1型是目前全球流行的主要毒株，2型目前只在西非流行）和其他相關(guān)的，并阻止副本在這些細(xì)胞內(nèi)的合成，從而抑制感染。

全、新、優(yōu)、品、好四大特點(diǎn)：

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新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

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