中文名稱  Rho GTP酶激活蛋白13抗體品牌 

英文名稱  Anti-SRGAP1

別    名 ARHGAP13; FLJ22166; KIAA1304; RGD1566260; Rho GTPase activating protein 13; SLIT ROBO Rho GTPase activating protein 1; SRGAP 1; SRGP1_HUMAN.

產(chǎn)品屬性：

Rho GTP酶激活蛋白13抗體品牌 濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep

產(chǎn)品類型   一抗  

研究領域    細胞生物 神經(jīng)生物學 信號轉(zhuǎn)導 G蛋白信號

蛋白分子量  predicted molecular weight: 124kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SRGAP1 (51-150aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Rho GTP酶激活蛋白13抗體品牌 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.

Function : SRGAP1 is a GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 it seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Subunit : Homodimer (Probable). Forms heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with ROBO1, CDC42 and RHOA. Interacts with FASLG.

Tissue Specificity : Expressed in brain, lung, kidney, and testis.

Similarity : Contains 1 FCH domain.

Contains 1 Rho-GAP domain.

Contains 1 SH3 domain.

Database links : UniProtKB/Swiss-Prot: Q7Z6B7.1

實驗流程：

全、新、優(yōu)、品、好四大特點：

Rho GTP酶激活蛋白13抗體品牌 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標準品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術團隊，產(chǎn)品一旦售出，實驗過程中遇到困難可提供在線技術咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。

技術外包服務:

★Rho GTP酶激活蛋白13抗體品牌 分子生物學：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學：基因合成、引物合成、基因測序、載體構建等

★蛋白工程：原核、哺乳動物蛋白表達系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細胞工程：細胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復、克隆形成)、細胞培養(yǎng)、細胞膜制備、穩(wěn)定細胞株構建、細胞RNAi技術等等。

正在熱銷的相關產(chǎn)品：

含三聯(lián)基元蛋白31 多克隆抗體  TRI31 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

含三聯(lián)基元蛋白35 多克隆抗體  TRI35 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

環(huán)指蛋白109/含三聯(lián)基元蛋白56 多克隆抗體  TRI56 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

tribbles同源物2 多克隆抗體  TRIB2 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

tribbles同源物3 多克隆抗體  TRIB3 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

β淀粉樣肽（31-35）/Aβ 31-35 抗體     整合素α4β7抗體

β淀粉樣肽 1-40（C端）抗體     整合素α3抗體

芳香基硫酸酯酶K抗體     整合素α3β1抗體(Integrin α3β1)

醛糖還原酶抗體     整合素α2抗體

血清白蛋白抗體     整合素α1抗體

血小板衍生生長因子受體α 多克隆抗體  PDGFR-α Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

血小板衍生生長因子受體β 多克隆抗體  PDGFR-β Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

PDHA1 多克隆抗體  PDHA1 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

PDK1 多克隆抗體  PDK1 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

PDK1 多克隆抗體  PDK1 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

茜草Radix Rubiac Cordifoliae Purpurin 羥基茜草素 81-54-9 C14H8O5 ≥98%

常春藤皂苷元IvyZcoGcnyucnHPLC≥98%，20mg/支

棉酚 Gossypol 303-45-7 20mg HPLC≥98% 用于含量測定

HPLC法含量測定辛伐他汀100601-2010032-8℃，避光100mg

Diflorasone Diacetate醋酸雙扶拉松標準品33564-31-7200mg

Rho GTP酶激活蛋白13抗體品牌鼠尾草酚 Carnosol 分 子 量：330.4200 CAS編號：5957-80-2 分子式：C20H26O4 別　　名：鼠尾草苦內(nèi)脂 基本用途：含量測定。

云南含笑Michelia yunnanensis Pinoresinol 4-O-glucoside 松脂醇-4-O-beta-D-葡萄糖苷 69251-96-3 C26H32O11 酞丁安(100060

供含量測定用太子參環(huán)肽B111887-201001常溫，避光20mg

Diwo7ium Inosinate肌苷酸二標準品4691-65-0500mg

花椒Zanthoxylum bungeanum Isotachioside 異它喬糖甙 31427-08-4 C13H18O8 ≥90%