神經(jīng)生長相關(guān)蛋白SCG10抗體規(guī)格 英文名稱  Anti-STMN2/SCG10

中文名稱  神經(jīng)生長相關(guān)蛋白SCG10抗體規(guī)格 

別    名 Neuronal growth associated protein; SCG 10; SCG10; SCG10 protein; SCGN 10; SCGN10; SGC 10; SGC10; Stathmin 2; Stathmin like 2; STMN 2; STMN-2; Superior cervical ganglia neural specific 10; Superior cervical ganglion 10 protein; Superiorcervical ganglia neural specific 10.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Cow, Horse

產(chǎn)品類型   一抗  

研究領(lǐng)域    免疫學(xué) 神經(jīng)生物學(xué)

蛋白分子量  predicted molecular weight: 20kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human STMN2/SCG10(1-43aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

神經(jīng)生長相關(guān)蛋白SCG10抗體規(guī)格 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010].

Function : Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.

Subunit : Interacts with MAPK8. Interacts with ITM2C.

Subcellular Location : Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon. Golgi apparatus. Endosome. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms.

Tissue Specificity : Neuron specific.

Post-translational modifications : Sumoylated.

Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.

Similarity : Belongs to the stathmin family.

Database links : UniProtKB/Swiss-Prot: Q93045.3

STMN2神經(jīng)生長相關(guān)蛋白又稱：頸上神經(jīng)節(jié)神經(jīng)特異性因子10，該蛋白可調(diào)節(jié)神經(jīng)細胞的分化、神經(jīng)細胞軸突的增殖及細胞骨架的構(gòu)成。

實驗流程：

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