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線粒體脫偶連蛋白2抗體品牌 英文名稱  Anti-UCP-2

中文名稱  線粒體脫偶連蛋白2抗體品牌 

別    名 Uncoupling Protein-2; UCP2; UCP 2; BMIQ4; Mitochondrial uncoupling protein 2; SLC25A8; UCPH; Uncoupling protein 2; Uncoupling protein 2 mitochondrial proton carrier; Solute carrier family 25 member 8; UCP2_MOUSE.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Pig, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域    細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào)

蛋白分子量  predicted molecular weight: 34kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from mouse UCP-2 C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

線粒體脫偶連蛋白2抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non sering thermogenesis, obesity and diabetes.

Function : UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Subunit : Acts as a dimer forming a proton channel (By similarity).

Subcellular Location : Mitochondrion inner membrane; Multi-pass membrane protein.

Tissue Specificity : Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Similarity : Belongs to the mitochondrial carrier family.

Contains 3 Solcar repeats.

Database links :

UniProtKB/Swiss-Prot: P70406.1

Entrez Gene: 7351 Human

Entrez Gene: 54315 Rat

Omim: 601693 Human

SwissProt: P55851 Human

SwissProt: P56500 Rat

Unigene: 80658 Human

Unigene: 13333 Rat

UCP-2又稱解耦聯(lián)蛋白 2 (UCP2 )是 1997年發(fā)現(xiàn)的一種新的解偶聯(lián)蛋白 ,它是線粒體內(nèi)膜載體家族的一員 。與其類似物UCP1相比 ,UCP2在棕色脂肪組織中含量較低 ,但在體內(nèi)分布廣泛。解耦聯(lián)蛋白(UCP)具有使線粒體呼吸鏈解耦聯(lián)作用,解耦聯(lián)所釋放的能量以熱能的形式散發(fā)。在對(duì)UCP與產(chǎn)熱關(guān)系的研究中,發(fā)現(xiàn)UCP2具有,并且可能是與相關(guān)聯(lián)的一個(gè)重要基因。

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