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髓系細(xì)胞觸發(fā)受體2抗體品牌 英文名稱  Anti-TREM2

中文名稱  髓系細(xì)胞觸發(fā)受體2抗體品牌 

別    名 TREM-2; TREM2a; TREM2b; TREM2c; Trggering receptor expressed on myeloid cells 2; Trggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; TREM2_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse

產(chǎn)品類型   一抗  

研究領(lǐng)域    免疫學(xué)

蛋白分子量  predicted molecular weight: 23kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TREM2

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

髓系細(xì)胞觸發(fā)受體2抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.

Function : May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Subunit : Interacts with TYROBP/DAP12 (By similarity).

Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).

Isoform 2: Secreted (Potential).

Isoform 3: Secreted (Potential).

Tissue Specificity : Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.

DISEASE : Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.

Similarity : Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links :

UniProtKB/Swiss-Prot: Q9NZC2.1

Entrez Gene: 54209 Human

Entrez Gene: 83433 Mouse

Omim: 605086 Human

SwissProt: Q9NZC2 Human

SwissProt: Q99NH8 Mouse

Unigene: 435295 Human

Unigene: 261623 Mouse

TREM-2是近年來發(fā)現(xiàn)應(yīng)的重要標(biāo)記物,也是感染性疾病的預(yù)警指標(biāo),與的嚴(yán)重程度相關(guān)。

TREM2屬于免疫球蛋白超家族TREM,表達(dá)于白細(xì)胞的細(xì)胞膜表面受體,TREM-選擇性地表達(dá)于中性粒細(xì)胞和部分單核細(xì)胞,它介導(dǎo)的信號傳導(dǎo)通路在的發(fā)生和級聯(lián)放大中起重要作用。

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