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Toll樣受體11抗體說(shuō)明書(shū) 英文名稱(chēng)  Anti-TLR11

中文名稱(chēng)  Toll樣受體11抗體說(shuō)明書(shū) 

別    名 Toll like receptor 11; Gm287; MGC129352; MGC129353; RGD1564460; TLR11_MOUSE.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類(lèi)型   polyclonal

交叉反應(yīng)   Mouse, Rat, Horse, Rabbit

產(chǎn)品類(lèi)型   一抗  

研究領(lǐng)域    免疫學(xué) 細(xì)胞膜受體

蛋白分子量  predicted molecular weight: 99kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from mouse TLR11

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Toll樣受體11抗體說(shuō)明書(shū) 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Toll like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.

Function : Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subunit : Binds MYD88 via their respective TIR domains. Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.

Subcellular Location : Membrane; Single-pass type I membrane protein.

Similarity : Belongs to the Toll-like receptor family.

Contains 10 LRR (leucine-rich) repeats.

Contains 1 TIR domain.

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