配體超家族成員14抗體品牌 英文名稱  Anti-TNFSF14

中文名稱  配體超家族成員14抗體品牌 

別    名 CD 258; CD258; CD258 antigen; Delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNF14_HUMAN; TNFSF 14; TNFSF14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor (ligand) superfamily, member 14; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily, member 14; Tumor necrosis factor receptor like 2; tumor necrosis factor receptor-like 2; Tumor necrosis factor superfamily member 14; Tumor necrosis factor superfamily member LIGHT.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域    細胞生物 t-淋巴細胞 細胞因子

蛋白分子量  predicted molecular weight: 26kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TNFSF14 C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

配體超家族成員14抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

Function : Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Subunit : Homotrimer.

Subcellular Location : Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.

Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.

Isoform 2: Cytoplasm.

Tissue Specificity : Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Post-translational modifications : N-glycosylated.

The soluble form of isoform 1 derives from the membrane form by proteolytic processing.

Similarity : Belongs to the tumor necrosis factor family.

Database links : UniProtKB/Swiss-Prot: O43557.2

實驗流程：

全、新、優(yōu)、品、好四大特點：

配體超家族成員14抗體品牌 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標準品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團隊，產(chǎn)品一旦售出，實驗過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。

正在熱銷的相關(guān)產(chǎn)品：

TBX2/T-box2(T-box Protein 2) 新型基因(多肽)Multi-class antibodies規(guī)格： 0.5mg

Anti-SMARCA4/SNF2 beta 基因SNF2β抗體Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh PEA15 星形膠質(zhì)細胞PEA15抗體 規(guī)格 0.2ml

CD31 濃縮液 0.1ml 進口分裝

Trk C 英文名稱： 酪酸激酶C抗體(神經(jīng)生長因子受體的一種) 0.1ml

Cystatin B 英文名稱： 胱抑素B/半胱酸蛋白酶抑制劑B抗體 0.2ml

Anti-SMARCA4/SNF2 beta 基因SNF2β抗體Multi-class antibodies規(guī)格： 0.1ml

E ELISA Kit 大鼠雌激素Multi-class antibodies規(guī)格： 48T

Anti-ARIP2a/FITC 熒光素標記激活素受體2A/激活素受體相互作用蛋白2a抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh FAM135B FAM135B蛋白抗體 規(guī)格 0.2ml

BMPR- II (Mouse Bone morphogenetic protein receptor II ) ELISA Kit 小鼠骨成型蛋白受體Ⅱ 96T

MSH2 英文名稱： 錯配修復蛋白2抗體 0.1ml

phospho-Androgen Receptor (Ser515) 英文名稱： 磷酸化雄激素受體抗體 0.1ml

Anti-ARIP2a/FITC 熒光素標記激活素受體2A/激活素受體相互作用蛋白2a抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-Trk C/FITC 熒光素標記酪氨酸激酶C抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Telomerase (TE) 端粒酶(催化亞單位)(多肽抗原)Multi-class antibodies規(guī)格： 0.5mg

酪氨酸酶抗體 Anti-Tyrosinase 0.1ml

Synapsin 1 英文名稱： 神經(jīng)突觸素1抗體 0.1ml

Estrogen Related Receptor beta 英文名稱： 雌激素相關(guān)受體β抗體 0.2ml

Rhesus antibody Rh Phospho-INPPL1(Tyr1135) 肌醇聚磷酸鹽磷酸酶樣蛋白1抗體 規(guī)格 0.1ml

Telomerase (TE) 端粒酶(催化亞單位)(多肽抗原)Multi-class antibodies規(guī)格： 0.5mg

大鼠內(nèi)皮素轉(zhuǎn)換酶2(ECE2)ELISA試劑盒 ，英文名： ECE2 ELISA Kit

人角化細胞生長因子(KGF)ELISA檢測試劑盒HumanKeratinocyteGrowthFactor,KGFELISAKit 96T/48T

魚白介素12(IL-12)免疫試劑盒 Fish Ierleukin 12,IL-12 ELISA Kit

CLIAKitforPARP(HumanPolyADPribosepolymerase)ELISAKit人多聚ADP核糖聚合酶規(guī)格：48T/96T

雙參數(shù)細胞周期S期流式細胞分析試劑盒10次

ELISAKitMDA人二規(guī)格：48T/96T

大鼠成纖維細胞生長因子3(FGF3)ELISA試劑盒 ，英文名： FGF3 ELISA Kit

Activation of human T cell junction proteins (LAT) ELISA Kit 人T細胞活化連接蛋白(LAT)ELISA試劑盒

RatEpidermalgrowthfactor,EGFELISAKit 大鼠表皮生長因子(EGF)ELISA試劑盒 96T/48T 進口分裝

CLIAKitforCryBeta(HumancrystalproteinsBeta)ELISAKit人晶體蛋白β規(guī)格：48T/96T

細胞腺苷酸激酶(Adenylatekinase)活性酶連續(xù)循環(huán)比色法定量檢測試劑盒20次

Ratdeoxypyridinoline,DPDELISAKit大鼠脫氧酚/脫氧啉(DPD)ELISA試劑盒規(guī)格：96T/48T

配體超家族成員14抗體品牌 大鼠多巴胺受體D2(DRD2)ELISA試劑盒 ，英文名： DRD2 ELISA Kit

Human C - type naiuretic peptide (CNP) ELISA Kit 人C型尿肽(CNP)ELISA試劑盒

Ratplaceagrowthfactor,PLGFELISAkit 大鼠胎盤生長因子(PLGF)ELISA試劑盒 96T/48T 進口分裝

CLIAKitforDA(Mousedopamine)ELISAKit小鼠多巴胺規(guī)格：48T/96T

細胞色素P450酶系列高通量篩選熒光檢測試劑盒500次

Ratglucoprotein130,gp130ELISAKit大鼠糖蛋白130(gp130)ELISA試劑盒規(guī)格：96T/48T

技術(shù)外包服務(wù):

★配體超家族成員14抗體品牌 分子生物學：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動物蛋白表達系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細胞工程：細胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復、克隆形成)、細胞培養(yǎng)、細胞膜制備、穩(wěn)定細胞株構(gòu)建、細胞RNAi技術(shù)等等。