酪氨酸激酶C抗體(神經(jīng)生長因子受體的一種)品牌 英文名稱  Anti-Trk C

中文名稱  酪氨酸激酶C抗體(神經(jīng)生長因子受體的一種)品牌 

別    名 EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETV6 NTRK3 fusion; GP145 TrkC; gp145(trkC); GP145TrkC; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor; NT 3 growth factor receptor; NT 3 growth factor receptor precursor; NT 3 receptor; NTRK3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; TrkC tyrosine kinase; Tyrosine kinase receptor C.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 激酶和磷酸酶 細(xì)胞膜受體

蛋白分子量  predicted molecular weight: 91kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Trk C N-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

酪氨酸激酶C抗體(神經(jīng)生長因子受體的一種)品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.

Function : Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

Subunit : Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity).

Subcellular Location : Membrane; Single-pass type I membrane protein.

Tissue Specificity : Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.

Post-translational modifications : Ligand-mediated auto-phosphorylation.

Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 protein kinase domain.

Database links : UniProtKB/Swiss-Prot: Q16288.2

神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）

此抗體針對NGF、BDNF、NT-3、NT-4等的受體包括trkA、trkB、trkC及NGFR。TrkC主要表達(dá)在腦神經(jīng)組織，NT-3能誘導(dǎo)trkC的酪氨酸磷酸化。

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