中文名稱  轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）費用 

英文名稱  Anti-TGF beta R2/TGFBR2

別    名 TGF beta Receptor II; AAT 3; AAT3; FAA 3; FAA3; HNPCC6; MFS 2; MFS2; RIIC; TAAD 2; TAAD2; TbetaR II; TGF beta receptor type 2; TGF beta receptor type II; TGF beta type II receptor; TGFB R2; TGFbeta RII; TGFBR 2; TGFBR2; TGFR 2; TGFR2; Transforming growth factor beta receptor II; Transforming growth factor beta receptor type II.

產(chǎn)品屬性：

轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）費用 濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 生長因子和激素 激酶和磷酸酶 細(xì)胞膜受體 細(xì)胞分化

蛋白分子量  predicted molecular weight: 62kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TGF beta R2

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）費用 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Function : Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Subunit : Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor.

Subcellular Location : Cell membrane; Single-pass type I membrane protein.

Post-translational modifications : Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.

DISEASE : Defects in TGFBR2 are the cause of hereditary non-polyposis colorectal cancer type 6 (HNPCC6) [MIM:614331]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. HNPCC6 is a type of colorectal cancer complying with the clinical criteria of HNPCC, except that the onset of cancer was beyond 50 years of age in all cases.

Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

細(xì)胞膜受體（Membrane Receptors)

TGFβR2及家族在進(jìn)化過程中結(jié)構(gòu)和功能高度保守。參與細(xì)胞因子信號傳導(dǎo)，調(diào)節(jié)多種細(xì)胞的生長、分化，在胚胎發(fā)育、組織器官形態(tài)發(fā)生、細(xì)胞的分化、增值及等方面都起著重要作用。此抗體主要用于散發(fā)性、及T細(xì)胞和頭頸部方面的研究。

實驗流程：

全、新、優(yōu)、品、好四大特點：

轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）費用 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊，產(chǎn)品一旦售出，實驗過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。

技術(shù)外包服務(wù):

★轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）費用 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動物蛋白表達(dá)系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細(xì)胞工程：細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。

正在熱銷的相關(guān)產(chǎn)品：

mmp-2(Human) 基質(zhì)金屬蛋白酶-2(人)Multi-class antibodies

Anti-phospho-CREB-1(Ser133) 磷酸化CREB-1抗體Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh NKR/Neurokin B receptor 神經(jīng)激肽B受體抗體 規(guī)格 0.2ml

Human growth-associated protein 43,GAP-43 ELISA Kit 人生長相關(guān)蛋白43 96T

TRH 英文名稱： 促甲狀腺素釋放激素抗體 0.1ml

CEP120 英文名稱： 中心體蛋白CEP120抗體 0.1ml

Anti-phospho-CREB-1(Ser133) 磷酸化CREB-1抗體Multi-class antibodies規(guī)格： 0.1ml

Mtp53(Mutant type p53) 突變型P53抗原Multi-class antibodies規(guī)格： 0.5mg

Anti-ASPP2/p53BP2 P53凋亡刺激蛋白2抗體Multi-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh phospho-AQP2(Ser261) 磷酸化水通道蛋白2抗體 規(guī)格 0.1ml

tau 濃縮液 0.1ml 進(jìn)口分裝

Ube2L3 英文名稱： 泛素蛋白連接酶L3抗體 0.2ml

DHRS7 英文名稱： 視網(wǎng)膜短鏈脫氫酶/還原酶家族7抗體 0.2ml

Anti-ASPP2/p53BP2 P53凋亡刺激蛋白2抗體Multi-class antibodies規(guī)格： 0.2ml

Anti-Synaptotagmin-4/FITC 熒光素標(biāo)記突觸結(jié)合蛋白4抗體IgGMulti-class antibodies規(guī)格： 0.2ml

ECG2 (sophagus cancer-related gene-2) 相關(guān)基因(抗原)Multi-class antibodies規(guī)格： 0.5mg

P-鈣粘附分子抗體 Anti-P-cadherin 0.1ml

SCGB3A1 英文名稱： 結(jié)合珠蛋白家族3A1抗體 0.2ml

ETV6 英文名稱： 轉(zhuǎn)錄因子ETV6抗體 0.2ml

Rhesus antibody Rh phospho-NF1(Ser2817) 磷酸化1型神經(jīng)抗體 規(guī)格 0.1ml

ECG2 (sophagus cancer-related gene-2) 相關(guān)基因(抗原)Multi-class antibodies規(guī)格： 0.5mg

大鼠尿苷二磷酸葡萄糖酸轉(zhuǎn)移酶1(UGT1)ELISA試劑盒 ，英文名： UGT1 ELISA Kit

人巨噬細(xì)胞移動抑制因子(MIF)ELISA檢測試劑盒HumanMacrophageMigrationInhibitoryFactor,MIFELISAKit 96T/48T

魚促腎上腺皮質(zhì)激素(ACTH)免疫試劑盒 Fish adrenocoicoopic hormone,ACTH ELISA kit

CLIAKitforPCNAELISAKit大鼠抗增殖細(xì)胞核抗原抗體規(guī)格：48T/96T

樹脂法去內(nèi)毒素試劑盒20次

ELISAKitCCP人補(bǔ)體調(diào)節(jié)蛋白規(guī)格：48T/96T

大鼠雌激素受體α(ERα)ELISA試劑盒 ，英文名： ERα ELISA Kit

Rat leukocyte differeiation aigen 30 (CD30) ELISA Kit 大鼠白細(xì)胞分化抗原30(CD30)ELISA試劑盒

Ratbasicfibroblastgrowthfactor,bFGFELISAKit 大鼠堿性成纖維生長因子(bFGF)ELISA試劑盒 96T/48T 進(jìn)口分裝

CLIAKitforCT(HumanCalcitonin)ELISAKit人降鈣素規(guī)格：48T/96T

細(xì)胞纖維蛋白溶酶原激活劑抑制物(PAI)活性化學(xué)發(fā)光法定量檢測試劑盒20次

RatdopamineD2receptor,D2RELISAKit大鼠多巴胺D2受體(D2R)ELISA試劑盒規(guī)格：96T/48T

轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）費用 大鼠二磷酸腺苷(ADP)ELISA試劑盒 ，英文名： ADP ELISA Kit

Rat ierleukin 11 (IL-11) ELISA Kit 大鼠白介素11(IL-11)ELISA試劑盒

Rattissueinhibitorsofmetalloproteinase3,TIMP-3ELISAKit 大鼠基質(zhì)金屬蛋白酶抑制因子3(TIMP-3)ELISA試劑盒 96T/48T 進(jìn)口分裝

CLIAKitforDF-Ab(Humandenguefeveraibody)ELISAKit人抗體規(guī)格：48T/96T

細(xì)胞乳酸脫氫酶(LDH)總活性酶動力比色法定量檢測試劑盒20次

RatGranulocyteColonyStimulatingFactor,G-CSFELISAKit大鼠粒細(xì)胞集落刺激因子(G-CSF)ELISA試劑盒規(guī)格：96T/48T