全、新、優(yōu)、品、好四大特點：

Tar DNA 結(jié)合蛋白43抗體費用 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊，產(chǎn)品一旦售出，實驗過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。

Tar DNA 結(jié)合蛋白43抗體費用 英文名稱  Anti-TDP-43/TARDBP

中文名稱  Tar DNA 結(jié)合蛋白43抗體費用 

別    名 TAR DNA-binding protein 43; ALS10; OTTHUMP00000002171; TAR DNA binding protein 43; TAR DNA binding protein; TDP 43; TDP43; TARDBP; tar DNA binding protein.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Cow, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域    神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)菌及 表觀遺傳學(xué)

蛋白分子量  predicted molecular weight: 45kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TDP-43

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Tar DNA 結(jié)合蛋白43抗體費用 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress -1 transcription by binding to the -1 long terminal repeat. [Subcellular Location] Nucleus. Note=Eliminated from nuclei of ubiquitinated inclusion-bearing neurons in FTLDU. [Tissue Specificity] Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq]

Function : DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Subcellular Location : Nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.

Tissue Specificity : Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Post-translational modifications : Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

DISEASE : Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:612069]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.

Similarity : Contains 2 RRM (RNA recognition motif) domains.

變異蛋白質(zhì)TDP-43 在額顳葉退行性（FTLD-U）和萎縮性側(cè)索硬化癥（ALS）中表達(dá)較高。TDP-43在大腦中堆積能導(dǎo)致神經(jīng)細(xì)胞衰竭,從而引發(fā)疾病肌萎縮性側(cè)索硬化（ALS，也被稱為Lou Gehrig氏?。?/p>

TDP-43這種是由大腦額葉的退化引起的，退化能延伸到顳葉。這是僅次于阿爾默海茲癥的讓65歲以下患者的第二種最常見的原因，通常影響40幾歲和50幾歲的人。TDP-43過去在疾者病理的錯誤折疊蛋白中缺失。識別出這個蛋白應(yīng)該有助于以及運動神經(jīng)元疾病的研究。

實驗流程：

正在熱銷的相關(guān)產(chǎn)品：

human-VEGF/ELISA 人內(nèi)皮生長因子Multi-class antibodies

Anti-Claudin-11 少突膠質(zhì)細(xì)胞跨膜蛋白抗體Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh nNos/NOS-1 合成酶-1抗體(神經(jīng)型) 規(guī)格 0.1ml

Human vitronectin,VNR ELISA Kit 人玻連蛋白/體外粘連蛋白 96T

TREM1 英文名稱： 髓系細(xì)胞觸發(fā)受體1抗體 0.2ml

CRTC3 英文名稱： CREB調(diào)節(jié)轉(zhuǎn)錄激活因子3抗體 0.2ml

Anti-Claudin-11 少突膠質(zhì)細(xì)胞跨膜蛋白抗體Multi-class antibodies規(guī)格： 0.1ml

Anti-CD337/NKp30/NCR3/FITC 熒光素標(biāo)記細(xì)胞毒性受體NK-p30抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-AT1R/AGTR1/FITC 熒光素標(biāo)記緊張素Ⅱ-1型受體抗體IgGMulti-class antibodies規(guī)格： 0.2ml

癌易感基因1抗體 Anti-BRCA1 0.2ml

Goat Anti-Chicken IgG/Cy5 Cy5標(biāo)記的羊抗雞IgG 0.1ml

FVT1 英文名稱： 濾泡型轉(zhuǎn)運蛋白1/II型慢性淋巴性抗體 0.2ml

Rhesus antibody Rh PPAR alpha α型-過氧化酶活化增生受體抗體 規(guī)格 0.1ml

Anti-AT1R/AGTR1/FITC 熒光素標(biāo)記緊張素Ⅱ-1型受體抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-Phospho-SHIP2 (Tyr580)/FITC 熒光素標(biāo)記磷酸化蛋白酪氨酸磷酸酶2抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Aromatase 芳香化酶(抗原)Multi-class antibodies規(guī)格： 0.5mg

神經(jīng)激肽A受體/K物質(zhì)受體抗體 Anti-NK-2R 0.2ml

SSTR4 英文名稱： 生長抑素受體4抗體 0.1ml

EVC1 英文名稱： 軟骨外胚層相關(guān)蛋白抗體 0.1ml

Rhesus antibody Rh Phospho-p63 (Ser160/Ser162) 磷酸化P63抑制基因抗體 規(guī)格 0.1ml

Aromatase 芳香化酶(抗原)Multi-class antibodies規(guī)格： 0.5mg

大鼠尿激酶型纖溶酶原激活物受體(PLAUR/uPAR)ELISA 試劑盒 96T/48T 試劑盒 組裝/原裝

人水通道蛋白3(AQP-3)免疫試劑盒 Human Aquaporin 3,AQP-3 ELISA Kit

MouseEsadiolreceptor,ERELISAKit小鼠雌二醇受體(ER)ELISA試劑盒規(guī)格：96T/48T

RatVitaminC,VCELISA試劑盒大鼠維生素C(VC)ELISA試劑盒規(guī)格：96T/48T

Humanmacrophageinflammatoryprotein2,MIP-2ELISA試劑盒人巨噬細(xì)胞炎性蛋白2(MIP-2)ELISA試劑盒規(guī)格：96T/48T

HumanPeosidineELISAKit人戊糖素(Peosidine)ELISA試劑盒規(guī)格：96T/48T

大鼠促黃體激素(LH)ELISA試劑盒 ，英文名： LH ELISA Kit

Mouse procollagen I carboxy terminal peptide (P I CP) ELISA Kit 小鼠Ⅰ型前膠原羧基端肽(PⅠCP)ELISA試劑盒

ELISA 小鼠環(huán)氧化酶-2 (mouse COX-2) 48T/96T 進(jìn)口分裝

CLIAKitforLHPoulyELISAKitLH禽類酶聯(lián)免疫ELISA試劑盒規(guī)格：48T/96T

通用型HHV6-A(HUMANHERPESVIRUS6-A)病毒定量PCR擴(kuò)增檢測試劑盒20次

ELISAKitVEGFR-3猴子內(nèi)皮細(xì)胞生長因子受體-3規(guī)格：48T/96T

Tar DNA 結(jié)合蛋白43抗體費用 大鼠法尼醇X受體(FXR)ELISA試劑盒 ，英文名： FXR ELISA Kit

Porcine endothelin 1 (ET-1) ELISA Kit 豬內(nèi)皮素1(ET-1)ELISA試劑盒

鴨特定基因序列(Duck)核酸檢測試劑盒(PCR-熒光探針法) 48T

CLIAKitforM-AChRELISAKit大鼠受體規(guī)格：48T/96T

體液游離氨基酸含量熒光定量檢測試劑盒20次

ELISAKitTGF-β1雞轉(zhuǎn)化生長因子β1規(guī)格：48T/96T

技術(shù)外包服務(wù):

★Tar DNA 結(jié)合蛋白43抗體費用 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動物蛋白表達(dá)系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細(xì)胞工程：細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。