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α誘導蛋白1抗體說明書 英文名稱  Anti-TNFAIP1

中文名稱  α誘導蛋白1抗體說明書 

別    名 tumor necrosis factor, alpha-induced protein 1-like; Tumor necrosis factor-alpha-induced protein 1; Tumor necrosis factor alpha induced protein 1 (endothelial).

產品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat

產品類型   一抗  

研究領域     細胞生物 免疫學 神經生物學 細胞凋亡

蛋白分子量  predicted molecular weight: 35kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TNFAIP1

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

α誘導蛋白1抗體說明書 產品應用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產品介紹 This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. Also known as: tumor necrosis factor, alpha-induced protein 1-like; Tumor necrosis factor-alpha-induced protein 1; Tumor necrosis factor alpha induced protein 1 (endothelial).

Function : Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Subcellular Location : Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.

Post-translational modifications : Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.

Similarity : Belongs to the BACURD family.

Contains 1 BTB (POZ) domain.

TNFAIP1 protein是第一個被鑒定受α誘導的蛋白,實驗證明TNFAIP1 蛋白可能參與DNA復制、合成、細胞凋亡以及人類的各種疾病等重要生理過程，但還有一些功能不清。

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