轉(zhuǎn)移生長因子β受體3抗體（TGF-βRⅢ，TGFβRⅢ）規(guī)格 英文名稱  Anti-TGF Beta R3

中文名稱  轉(zhuǎn)移生長因子β受體3抗體（TGF-βRⅢ，TGFβRⅢ）規(guī)格 

別    名 Beta glycan; Betaglycan; Betaglycan proteoglycan; BGCAN; TGF beta receptor type 3; TGF beta receptor type III; TGF beta Receptor III; TGFB R3; TGFBR 3; TGFBR3; TGFR 3; TGFR3; Transforming Growth Factor Beta Receptor III; Transforming growth factor beta receptor III betaglycan 300kDa.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Pig, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞凋亡 生長因子和激素 激酶和磷酸酶

蛋白分子量  predicted molecular weight: 94kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TGFBR3

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

轉(zhuǎn)移生長因子β受體3抗體（TGF-βRⅢ，TGFβRⅢ）規(guī)格 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Membrane Receptors

Transforming growth factor beta is a multifunctional cytokine known to modulate several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. There are 3 forms encoded by separate genes TGFB1, TGFB2, and TGFB3. The diverse effects of TGF beta are mediated by the TGF beta receptors and cell surface binding proteins. In addition to type I TGF beta receptor (TGFBR1) and type II (TFGBR2), type III (TGF beta III receptor) has been identified. It is a glycoprotein that binds TGF beta and exists in both a membrane bound and a soluble form. It may serve as a receptor accessory molecule in both the TGF beta and fibroblast growth factor systems. TGF beta III receptor lacks a recognizable signaling domain and has no clearly defined role in TGF beta signaling. Endothelial cells undergoing epithelial mesenchymal transformation express TGF beta III receptor, and TGF beta III receptor specific antisera inhibits mesenchyme formation and migration. Misexpression of TGF beta III receptor in nontransforming ventricular endothelial cells conferrs transformation in response to TGFB2. These results support a model where TGF beta III receptor localizes transformation in the heart and plays an essential, nonredundant role in TGF beta signaling.

TGF beta III receptor, or beta glycan, can function as an inhibin coreceptor with ActRII. TGF beta III receptor binds inhibin with high affinity and enhances binding in cells coexpressing ActRII and TGF beta III receptor. Inhibin forms crosslinked complexes with both recombinant and endogenously expressed TGF beta III receptor and ActRII. TGF beta III receptor confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone. The ability of TGF beta III receptor to inhibit or to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as coreceptors modulating ligand receptor sensitivity, selectivity, and function. Beta arrestin 2 binds to TGF beta III receptor, triggered by phosphorylation of the receptor on its cytoplasmic domain, likely at threonine 841. Phosphorylation is mediated by TGFBR2, which is itself a kinase, rather than by a G protein coupled receptor kinase. Association with beta arrestin 2 leads to internalization of both receptors and downregulation of TGF beta signaling. The regulatory actions of beta arrestins are broader than previously appreciated, extending to the TGF beta receptor family as well.

Function : Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Subcellular Location : Secreted. Secreted > extracellular space. Cell membrane. Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Post-translational modifications : Extensively modified by glycosaminoglycan groups (GAG).

Similarity : Contains 1 ZP domain.

轉(zhuǎn)化生長因子β受體Ⅲ，TGFβRⅢ

實驗流程：

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