![]() |
產(chǎn)地 | 進(jìn)口、國(guó)產(chǎn) |
品牌 | 上海莼試 |
保存條件 | Store at -20 °C |
貨號(hào) | CS11749 |
應(yīng)用范圍 | ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
CAS編號(hào) | |
抗體名 | Anti-TTC21B |
克隆性 | |
靶點(diǎn) | 詳見說(shuō)明書 |
適應(yīng)物種 | 詳見說(shuō)明書 |
形態(tài) | 詳見說(shuō)明書 |
宿主 | 詳見說(shuō)明書 |
亞型 | IgG |
標(biāo)識(shí)物 | 詳見說(shuō)明書 |
濃度 | 1mg/1ml% |
免疫原 | KLH conjugated synthetic peptide derived from human TTC21B |
技術(shù)外包服務(wù):
★四聚體多肽蛋白21B抗體費(fèi)用 分子生物學(xué):質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué):基因合成、引物合成、基因測(cè)序、載體構(gòu)建等
★蛋白工程:原核、哺乳動(dòng)物蛋白表達(dá)系統(tǒng)等
★病毒包裝:腺病毒、慢病毒等
★抗體工程:磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等
★細(xì)胞工程:細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。
實(shí)驗(yàn)流程:
四聚體多肽蛋白21B抗體費(fèi)用 英文名稱 Anti-TTC21B
中文名稱 四聚體多肽蛋白21B抗體費(fèi)用
別 名 ATD4; JBTS11; Nbla10696; NPHP12; Putative protein product of Nbla10696; Tetratricopeptide repeat protein 21B; THM1; TPR repeat protein 21B; TT21B_HUMAN; Ttc21b.
產(chǎn)品屬性:
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來(lái)源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep
產(chǎn)品類型 一抗
研究領(lǐng)域 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞
蛋白分子量 predicted molecular weight: 150kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human TTC21B
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
四聚體多肽蛋白21B抗體費(fèi)用 產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
Function : May negatively modulate SHH signal transduction and may play a role in retrograde intraflagellar transport in cilia.
Subcellular Location : Cytoplasm
DISEASE : Note=Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. TTC21B is causally associated with diverse ciliopathies, and also acts as a modifier gene across the ciliopathy spectrum. TTC21B mutations interact in trans with mutations in other ciliopathy-causing genes and contribute to disease manifestation and severity.
Defects in TTC21B are the cause of nephronophthisis type 12 (NPHP12) [MIM:613820]. NPHP12 is an autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Some patients manifest extra-renal features including retinal, skeletal and central nervous system defects.
Defects in TTC21B are the cause of asphyxiating thoracic dystrophy type 4 (ATD4) [MIM:613819]. ATD4 is an autosomal recessive chondrodysplasia characterized by a severely constricted thoracic cage, short-limbed short stature, and polydactyly. It often leads to death in infancy because of respiratory insufficiency. Retinal degeneration, cystic renal disease and hepatic disease can be present in affected individuals who survive early childhood.
Defects in TTC21B may be a cause of Bardet-Biedl syndrome (BBS) [MIM:209900]. A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.
Defects in TTC21B may be a cause of Joubert syndrome (JBTS) [MIM:213300]. A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease.
Similarity : Belongs to the TTC21 family.
Contains 19 TPR repeats.
Database links : UniProtKB/Swiss-Prot: Q7Z4L5.2
全、新、優(yōu)、品、好四大特點(diǎn):
四聚體多肽蛋白21B抗體費(fèi)用 全:公司提供上萬(wàn)種產(chǎn)品,涵蓋了生物試劑,elisa試劑盒,標(biāo)準(zhǔn)品,培養(yǎng)基,原裝耗材,抗體、培養(yǎng)基、ATCC細(xì)胞等,基本上各種科研所需產(chǎn)品在我司都能找到。
新:產(chǎn)品更新速度較快,基本上每周都有新產(chǎn)品出現(xiàn)。
優(yōu):產(chǎn)品質(zhì)量好,投訴比較少。
好:我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊(duì),產(chǎn)品一旦售出,實(shí)驗(yàn)過(guò)程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時(shí)沒有任何的后顧之憂。
正在熱銷的相關(guān)產(chǎn)品:
Anti-OPG /FITC 熒光素標(biāo)記骨保護(hù)蛋白/護(hù)骨素抗體IgGMulti-class antibodies規(guī)格: 0.2ml
Rabbit Anti-pig IgG/HRP 辣根過(guò)氧化物酶標(biāo)記兔抗豬IgGMulti-class antibodies規(guī)格: 0.1ml
即刻早期基因抗體 Anti-c-fos 0.1ml
Rabbit Anti-horse IgM/Alexa Fluor 555 Alexa Fluor 555標(biāo)記的兔抗馬IgM 0.1ml
FGF12 英文名稱: 成纖維細(xì)胞生長(zhǎng)因子12抗體 0.2ml
Rhesus antibody Rh PKC epsilon 蛋白激酶C抗體 規(guī)格 0.1ml
Rabbit Anti-pig IgG/HRP 辣根過(guò)氧化物酶標(biāo)記兔抗豬IgGMulti-class antibodies規(guī)格: 0.1ml
IL-18/IGIF(Interleukin-18) 白細(xì)胞介素-18/干擾素γ誘導(dǎo)因子Multi-class antibodies規(guī)格: 0.5mg
Anti-ACTH (7-23) 促腎上腺皮質(zhì)激素ACTH (7-23)抗體Multi-class antibodies規(guī)格: 0.1ml
Rhesus antibody Rh phospho-CDK7 (Thr170) 磷酸化周期素依賴性激酶7抗體 規(guī)格 0.1ml
羊IgG干粉 10mg/50mg/100mg 國(guó)產(chǎn)
WDR68 英文名稱: WDR68蛋白抗體 0.1ml
DEC-205/CD205/Ly75 英文名稱: 淋巴細(xì)胞抗原75抗體 0.2ml
Anti-ACTH (7-23) 促腎上腺皮質(zhì)激素ACTH (7-23)抗體Multi-class antibodies規(guī)格: 0.1ml
Anti-AFP/Biotin 生物素化鼠抗人甲胎蛋白單克隆抗體(包被)IgGMulti-class antibodies規(guī)格: 0.2ml
Dynamin 2(Anti-Human Dynamin-2 ) 鳥苷三磷酸酶-發(fā)動(dòng)蛋白2抗體Multi-class antibodies規(guī)格: 0.5mg
Apollon凋亡抑制蛋白抗體 Anti-Apollon 0.1ml
ZNF598 英文名稱: 鋅指蛋白598抗體 0.2ml
Dermokine beta 英文名稱: Dermokine β蛋白抗體 0.2ml
Rhesus antibody Rh phospho-Ep300 (Ser1834) 磷酸化轉(zhuǎn)錄接頭蛋白EP300抗體 規(guī)格 0.1ml
Dynamin 2(Anti-Human Dynamin-2 ) 鳥苷三磷酸酶-發(fā)動(dòng)蛋白2抗體Multi-class antibodies規(guī)格: 0.5mg
人癌標(biāo)志物-CA153ELISA 試劑盒 96T/48T 試劑盒 組裝/原裝
小鼠樣生長(zhǎng)因子結(jié)合蛋白1(IGFBP-1)免疫試劑盒 Mouse Insulin-like growth factor binding protein 1,IGFBP-1 ELISA Kit
桿菌(YP)核酸檢測(cè)試劑盒(PCR-熒光探針法) 48T
HumanProteinCELISA試劑盒人蛋白C(ProteinC)ELISA試劑盒規(guī)格:96T/48T
NGAL小鼠中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運(yùn)載蛋白規(guī)格:48T/96T
HumanComplemefragme3a,C3aELISAKit人補(bǔ)體片斷3a(C3a)ELISA試劑盒規(guī)格:96T/48T
大鼠水通道蛋白4(AQP-4)ELISA試劑盒 ,英文名: AQP-4 ELISA Kit
人血清(NO)ELISA檢測(cè)試劑盒Humanniicoxide,NOELISAKit 96T/48T
蝌蚪雌二醇(E2)免疫試劑盒 Tadpole Esadiol,E2 ELISA kit
CLIAKitforPPAR-Gamma(HumanPeroxisomeProliferator-activatedreceptorGamma)ELISAKit人過(guò)氧化物酶體增殖因子活化受體γ規(guī)格:48T/96T
石蠟切片組織IKB-ALPHA蛋白表達(dá)熒光顯微鏡檢測(cè)試劑盒10/20次
ELISAKitSP-C人肺表面活性物質(zhì)相關(guān)蛋白C規(guī)格:48T/96T
四聚體多肽蛋白21B抗體費(fèi)用 大鼠維生素D3(VD3)ELISA 試劑盒 96T/48T 試劑盒 組裝/原裝
人維生素D結(jié)合蛋白(DBP)免疫試劑盒 Human DBP ELISA Kit
脂氧合酶(LOX)測(cè)試盒 紫外分光光度法 50管/48樣
RatProinsulin,PIELISA試劑盒大鼠原(PI)ELISA試劑盒規(guī)格:96T/48T
HumanIerferoninducibleT-cellChemoatacta,I-TACELISA試劑盒人干擾素誘導(dǎo)T細(xì)胞趨化因子(ITAC/CXCL11)ELISA試劑盒規(guī)格:96T/48T
Humanmitoticspindleapparatusaibody,MSAELISAKit人抗紡錘體抗體(MSA)ELISA試劑盒規(guī)格:96T/48T