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甲狀腺轉(zhuǎn)錄因子-2抗體規(guī)格 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

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甲狀腺轉(zhuǎn)錄因子-2抗體規(guī)格 英文名稱  Anti-TTF-2/FOXE1

中文名稱  甲狀腺轉(zhuǎn)錄因子-2抗體規(guī)格 

別    名 FKH L15; FKHL 15; FKHL15; Forkhead (Drosophila) like 15; forkhead (Drosophila)-like 15; forkhead box E1; Forkhead box E2; Forkhead box protein E1; Forkhead drosophila homolog like 15; Forkhead like 15; Forkhead related protein FKHL 15; Forkhead related protein FKHL15; FOX E1; FOX E2; FOXE 1; FOXE 2; FOXE-2; FOXE1; FOXE2; HFKH 4; HFKH4; HFKL 5; HFKL5; homolog-like 15; thyroid transcription factor 2; thyroid transcription factor-2; TITF 2; TITF2; TTF 2; TTF-2; TTF2.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Pig, Cow

產(chǎn)品類型   一抗  

研究領(lǐng)域    轉(zhuǎn)錄調(diào)節(jié)因子

蛋白分子量  predicted molecular weight: 41kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TTF-2 C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

甲狀腺轉(zhuǎn)錄因子-2抗體規(guī)格 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Thyroid transcription factor 2 (TITF2; Forkhead; TH; also known as a "winged helix") . FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. TISSUE SPECIFICITY: Thyroid and lung. subcellular location: Nucleus Belongs to the NK-2 homeobox family.

Function : Probable transcription factor. Could be involved in thyroid gland organogenesis.

Subcellular Location : Nucleus (Potential).

Tissue Specificity : Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.

Post-translational modifications : Phosphorylated.

DISEASE : Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS) [MIM:241850]. BLS is associated with thyroid agenesis, cleft palate and choanal atresia.

Similarity : Contains 1 fork-head DNA-binding domain.

甲狀腺轉(zhuǎn)錄因子-2(TTF-2)在個體發(fā)生中的表達(dá)具有高度組織特異性和發(fā)育階段特異性,是甲狀腺、腭等器官正常發(fā)育的重要調(diào)節(jié)因子。

只要用于研究TTF-2基因活動規(guī)律和表達(dá)模式發(fā)生的變化,對胚胎發(fā)育過程中器官發(fā)生和產(chǎn)生的影響狀況。

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