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瞬時(shí)受體電位離子通道蛋白1抗體（M亞家族）說明書 英文名稱  Anti-TRPM1

中文名稱  瞬時(shí)受體電位離子通道蛋白1抗體（M亞家族）說明書 

別    名 Long transient receptor potential channel 1; LTRPC1; Melastatin 1; Melastatin-1; MLSN1; Transient receptor potential cation channel subfamily M member 1; Transient receptor potential cation channel, subfamily M, member 1; TRPM1; TRPM1 protein; TRPM1_HUMAN; Weakly similar to F54D1.5 [C.elegans].

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 通道蛋白

蛋白分子量  predicted molecular weight: 182kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TRPM1

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

瞬時(shí)受體電位離子通道蛋白1抗體（M亞家族）說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:50-200

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.

Involvement in disease:

Defects in TRPM1 are the cause of congenital stationary night blindness type 1C (CSNB1C) [MIM:613216]. A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.

Function : Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.

Subcellular Location : Cell membrane

Tissue Specificity : Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.

DISEASE : Defects in TRPM1 are the cause of congenital stationary night blindness type 1C (CSNB1C) [MIM:613216]. A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.

Similarity : Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily.

Database links :

Entrez Gene: 4308 Human

Entrez Gene: 17364 Mouse

Entrez Gene: 361586 Rat

Omim: 603576 Human

SwissProt: O75560 Human

SwissProt: Q7Z4N2 Human

SwissProt: Q2TV84 Mouse

SwissProt: Q2WEA4 Rat

SwissProt: Q2WEA5 Rat

Unigene: 155942 Human

Unigene: 38875 Mouse

Unigene: 211311 Rat

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