微管相關蛋白Tau421抗體規(guī)格 英文名稱  Anti-Tau421

中文名稱  微管相關蛋白Tau421抗體規(guī)格 

別    名 DDPAC; FTDP 17; FTDP17; G protein beta1/gamma2 subunit interacting factor 1; MAPTL; Microtubule associated protein tau, isoform 4; MSTD; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; PHF tau.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse

產(chǎn)品類型   一抗  

研究領域    神經(jīng)生物學 信號轉導 細胞骨架 細胞外基質 Alzheimer's

蛋白分子量  predicted molecular weight: 79kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Tau421

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

微管相關蛋白Tau421抗體規(guī)格 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Tau421 promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C terminus binds axonal microtubules while the N terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. There are nine named isoforms.

Subcellular Location : Cytoplasm, cytosol, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

實驗流程：

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