“冷”蛋白TRPM8抗體品牌 英文名稱  Anti-TRPM8

中文名稱  “冷”蛋白TRPM8抗體品牌 

別    名 LTrpC-6; LTrpC6 antibody Short form of the TRPM8 cationic channel; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; Trp p8; Trp-p8; Trpm8; TRPM8_HUMAN; TRPP8; MGC2849; transient receptor potential-p8; Long transient receptor potential channel 6.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat, Dog, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域     細胞生物 免疫學 神經(jīng)生物學 信號轉(zhuǎn)導

蛋白分子量  predicted molecular weight: 128kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TRPM8

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

“冷”蛋白TRPM8抗體品牌 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Function : Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Subunit : Homotetramer (By similarity).

Subcellular Location : Membrane; Multi-pass membrane protein (Probable).

Tissue Specificity : Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.

Similarity : Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 ub-subfamily.

Database links :

Entrez Gene: 79054 Human

Entrez Gene: 171382 Mouse

Entrez Gene: 171384 Rat

Omim: 606678 Human

SwissProt: Q7Z2W7 Human

SwissProt: Q8R4D5 Mouse

SwissProt: Q8R455 Rat

Unigene: 366053 Human

Unigene: 218753 Mouse

Unigene: 81225 Rat

TRPM8與感應熱和辣的蛋白質(zhì)屬于同一家族，它存在于特定神經(jīng)細胞的細胞膜上，成為響應外界信號的開關(guān)通道?？茖W家研究發(fā)現(xiàn)，當溫度低于27攝氏度或者醇存在的條件下，TRPM8通道都會打開，使鈣離子等帶正電的粒子進入細胞。 TRPM8的蛋白質(zhì)在產(chǎn)生冷知覺的過程中起著主導作用，并且控制著低溫對機體的緩解效果, TRPM8故稱是“冷”蛋白。

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