中文名稱(chēng)  硫氧還蛋白結(jié)合蛋白2抗體說(shuō)明書(shū) 

英文名稱(chēng)  Anti-TXNIP

別    名 ;THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN.

產(chǎn)品屬性：

硫氧還蛋白結(jié)合蛋白2抗體說(shuō)明書(shū) 濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類(lèi)型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Rabbit

產(chǎn)品類(lèi)型   一抗  

研究領(lǐng)域     免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子

蛋白分子量  predicted molecular weight: 44kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TXNIP

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

硫氧還蛋白結(jié)合蛋白2抗體說(shuō)明書(shū) 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt).

Function : May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Subunit : Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

Subcellular Location : Cytoplasm

Post-translational modifications : Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

Similarity : Belongs to the arrestin family.

Database links : UniProtKB/Swiss-Prot: Q9H3M7.1

硫氧還蛋白結(jié)合蛋白-2 (TRX-binding protein-2，TBP-2)又稱(chēng):維生素D3上調(diào)蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或稱(chēng)硫氧還蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。

TBP-2與硫氧還蛋白(thioredoxin，TRX)的活性部位結(jié)合，抑制其活性，除了參與多種氧化應(yīng)激反應(yīng)，還具有多種生物學(xué)功能。

有學(xué)者認(rèn)為：TBP-2與密切相關(guān)，有些組織中，TBP-2表達(dá)降低或缺失。TBP-2表達(dá)增高時(shí)，細(xì)胞周期停滯，細(xì)胞繁殖受到抑制。目前已成為研究的重要靶點(diǎn)。

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技術(shù)外包服務(wù):

★硫氧還蛋白結(jié)合蛋白2抗體說(shuō)明書(shū) 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測(cè)序、載體構(gòu)建等

★蛋白工程：原核、哺乳動(dòng)物蛋白表達(dá)系統(tǒng)等

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