中文名稱  神經(jīng)元電壓門控鈉通道蛋白β2/Na+ CP type IIβ抗體品牌 

英文名稱  Anti-SCN2B

別    名 Neuronal voltage gated sodium channel beta 2 subunit; Scn 2b; Scn2b; SCN2B_HUMAN; Sodium channel beta 2 subunit; Sodium channel subunit beta 2; Sodium channel subunit beta-2; Sodium channel voltage gated type II beta; Sodium channel voltage gated type II beta polypeptide.

產(chǎn)品屬性：

神經(jīng)元電壓門控鈉通道蛋白β2/Na+ CP type IIβ抗體品牌 濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域    神經(jīng)生物學(xué) 通道蛋白 細(xì)胞膜受體

蛋白分子量  predicted molecular weight: 21kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SCN2B

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

神經(jīng)元電壓門控鈉通道蛋白β2/Na+ CP type IIβ抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type II beta(sodium channel, voltage-gated, type II, beta), also known as SCN2B, is a 215 amino acid single-pass type I membrane protein that plays a critical role in the expression and assembly of the heterotrimeric complex of the sodium channel and interacts with Tenascin-R to influence the clustering and regulation of sodium channels at nodes of Ranvier. Expressed specifically in brain, Na+ CP type II beta contains one Ig-like C2-type (immunoglobulin-like) domain and is encoded by a gene that maps to human chromosome 11q23.3 and mouse chromosome 9 A5.2.

Function : Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.

Subunit : [SUBUNIT] The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR (By similarity).

Subcellular Location : Membrane; Single-pass type I membrane protein.

Tissue Specificity : Brain specific.

Similarity : Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Database links : UniProtKB/Swiss-Prot: O60939.1

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技術(shù)外包服務(wù):

★神經(jīng)元電壓門控鈉通道蛋白β2/Na+ CP type IIβ抗體品牌 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動(dòng)物蛋白表達(dá)系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

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