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磷酸化絲氨酸/蘇氨酸蛋白激酶39抗體說明書 英文名稱  Anti-phospho-STK39(Se*5)

中文名稱  磷酸化絲氨酸/蘇氨酸蛋白激酶39抗體說明書 

別    名 STK39 (phospho S325); p-STK39 (phospho S325); p-PASK (phospho S325); p-SPAK (phospho S325); PASK; Proline alanine rich STE20 related kinase; Serine threonine kinase 39 (STE20/SPS1 homolog yeast); Serine threonine kinase 39; Serine/threonine protein kinase 39; Serine/threonine-protein kinase 39; Small intestine SPAK like kinase; SPAK; Ste 20 related kinase; Ste-20-related kinase; Ste20 like protein kinase; STE20/SPS1 homolog; STE20/SPS1 related proline alanine rich protein kinase; STE20/SPS1-related proline-alanine-rich protein kinase; STK 39; Stk39; STK39_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Sheep

產(chǎn)品類型   一抗 磷酸化抗體  

研究領(lǐng)域     細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 激酶和磷酸酶

蛋白分子量  predicted molecular weight: 59kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthesised phosphopeptide derived from human STK39 around the phosphorylation site of Se*5

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

磷酸化絲氨酸/蘇氨酸蛋白激酶39抗體說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. SPAK, also known as STK39 (serine threonine kinase 39), DCHT or PASK, is a 547 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one protein kinase domain. Expressed predominately in pancreas, brain, heart, lung, liver and testis, SPAK functions as a Ser/Thr protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to be involved in mediating stress-activated signals. The gene encoding SPAK maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.

Function : May act as a mediator of stress-activated signals.

Subunit : The phosphorylated form forms a complex with WNK2 (By similarity).

Subcellular Location : Cytoplasm. Nucleus. Nucleus when caspase-cleaved.

Tissue Specificity : Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

Post-translational modifications : Phosphorylated at Ser-309 by PRKCQ.

Similarity : Belongs to the protein kinase superfamily.

STE Ser/Thr protein kinase family. STE20 subfamily.

Contains 1 protein kinase domain.

Database links : UniProtKB/Swiss-Prot: Q9UEW8.3

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