互養(yǎng)蛋白1,2,3抗體說明書 英文名稱  Anti-Syntrophin-1+2+3

中文名稱  互養(yǎng)蛋白1,2,3抗體說明書 

別    名 SNTA1_HUMAN; SNTB1_HUMAN; SNTB2_HUMAN; Beta-1-syntrophin; Beta-2-syntrophin; alpha-1-syntrophin; Syntrophin-1; Syntrophin-2; Syntrophin-3; 59kDa dystrophin-associated protein A1 basic component 2; SNT1; SNT2; SNT3; SNTA1; SNTB1; SNTB2; Syntrophin alpha 1; Syntrophin beta 1; Syntrophin beta 2.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域    細胞生物 神經(jīng)生物學(xué) 結(jié)合蛋白 跨膜蛋白 細胞膜蛋白

蛋白分子量  predicted molecular weight: 59kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Syntrophin-1+2+3

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

互養(yǎng)蛋白1,2,3抗體說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].

Function : Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.

Subunit : Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.

Subcellular Location : Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction. In insulinoma cell line, it is enriched in secretory granules.

Tissue Specificity : Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.

Post-translational modifications : Phosphorylated. Partially dephosphorylated upon insulin stimulation.

Similarity : Belongs to the syntrophin family.

Contains 1 PDZ (DHR) domain.

Contains 2 PH domains.

Contains 1 SU (syntrophin unique) domain.

Database links : UniProtKB/Swiss-Prot: Q13425.1

NCBI Reference Sequence: NP_006741.1

實驗流程：

全、新、優(yōu)、品、好四大特點：

互養(yǎng)蛋白1,2,3抗體說明書 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標準品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團隊，產(chǎn)品一旦售出，實驗過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。

正在熱銷的相關(guān)產(chǎn)品：

Inhibin beta B 抑制素βB抗原Multi-class antibodies規(guī)格： 0.5mg

Anti-ADAMTS12 整合素樣金屬蛋白酶與凝血酶1型-12抗體Multi-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh Phospho-cdc25A (Ser76) 磷酸化細胞分裂周期蛋白25抗體 規(guī)格 0.1ml

吉姆薩染色液 10ml Sigma原料

VDAC 英文名稱： 等電壓依賴性陰離子通道抗體 0.2ml

Dynamin 1 英文名稱： 酶動力蛋白1抗體 0.1ml

Anti-ADAMTS12 整合素樣金屬蛋白酶與凝血酶1型-12抗體Multi-class antibodies規(guī)格： 0.2ml

Anti-phospho c-kit/SCFR/CD117(pTyr936)FITC 熒光素標記抗磷酸化原癌基因c-kit抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rabbit Anti-Guinea IgG 兔抗豚鼠IgG (親和層析純化)Multi-class antibodies規(guī)格： 1mg

胰素樣肽-2抗體 Anti-GLP-2 0.2ml

Rabbit Anti-Bovine IgM/PE PE標記的兔抗IgM 0.1ml

Factor VIII 英文名稱： 凝血因子8/第八凝血因子/第八因子相關(guān)抗原抗體 0.1ml

Rhesus antibody Rh Phospho-SHIP1 (Tyr1020) 磷酸化SH2結(jié)構(gòu)含磷酸肌醇SHIP1抗體 規(guī)格 0.1ml

Rabbit Anti-Guinea IgG 兔抗豚鼠IgG (親和層析純化)Multi-class antibodies規(guī)格： 1mg

C14orf174 英文名稱： 14號染色體開放閱讀框174 0.2ml

EBP50 英文名稱： 細胞骨架連接質(zhì)膜蛋白抗體 0.1ml

促甲狀腺素受體抗體 Anti-TSHR 0.1ml

Anti-TRF2/FITC 熒光素標記端粒結(jié)合蛋白2抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh phospho-IRAK4(Thr345) 磷酸化白介素-1受體相關(guān)激酶4抗體 規(guī)格 0.1ml

Alpha-Synuclein 核突觸蛋白(抗原)Multi-class antibodies規(guī)格： 0.5mg

QGY-7701, 人細胞

HSF 人皮膚成纖維樣細胞

SERPINA6 Others Human 人 SerpinA6 / CBG 人細胞裂解液 (陽性對照)

CM-H131人角膜成纖維細胞完全培養(yǎng)基100mL

人肝竇內(nèi)皮細胞HHSEC

人細胞;A549 [A-549] 人腦成纖維細胞完全培養(yǎng)基 100mL

CL-0020Acc-2(人涎腺腺樣囊性癌細胞)5×106cells/瓶×2

AMIGO2 Others Human 人 AMIGO2 人細胞裂解液 (陽性對照)

間充質(zhì)干細胞脂肪細胞分化生長添加物MADS

3AO細胞，人細胞系 大鼠主動脈平滑肌細胞,RSMC細胞 小腸粘膜上皮細胞Many types of cells包裝：5 × 105次方(1ml)

G-401(人Wilms細胞) 5×106cells/瓶×2

HCH Pellet 人類軟骨細胞團塊 > 1 mio.cells 成纖維細胞cDNAHMF cDNA

互養(yǎng)蛋白1,2,3抗體說明書 QGY-7701, 人細胞

HSF 人皮膚成纖維樣細胞

SERPINA6 Others Human 人 SerpinA6 / CBG 人細胞裂解液 (陽性對照)

CM-H131人角膜成纖維細胞完全培養(yǎng)基100mL

人肝竇內(nèi)皮細胞HHSEC

人細胞;A549 [A-549] 人腦成纖維細胞完全培養(yǎng)基 100mL

技術(shù)外包服務(wù):

★互養(yǎng)蛋白1,2,3抗體說明書 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動物蛋白表達系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細胞工程：細胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細胞培養(yǎng)、細胞膜制備、穩(wěn)定細胞株構(gòu)建、細胞RNAi技術(shù)等等。