磷酸化G蛋白信號轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體說明書 英文名稱  Anti-phospho-RGS19(Tyr143)

中文名稱  磷酸化G蛋白信號轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體說明書 

別    名 RGS19(phospho Y143); RGS19(phospho Ser143); G alpha interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; RGSGAIP; RGS19_HUMAN; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, chk, shp, dog, hrs, cow

產(chǎn)品類型   一抗 磷酸化抗體  

研究領(lǐng)域     免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子

蛋白分子量  predicted molecular weight: 25kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human RGS19 around the phosphorylation site of Tyr143 [LI(p-Y)ED]

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

磷酸化G蛋白信號轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase activating protein that functions to down regulate Galpha i/Galpha q linked signaling.

Function : Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Subunit : Interacts with GIPC PDZ domain.

Subcellular Location : Membrane; Lipid-anchor.

Tissue Specificity : Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Post-translational modifications : Fatty acylated. Heavily palmitoylated in the cysteine string motif.

Phosphorylated, mainly on serine residues.

Similarity : Contains 1 RGS domain.

Database links : UniProtKB/Swiss-Prot: P49795.1

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