磷脂酰乙醇胺結(jié)合蛋白1抗體品牌 英文名稱  Anti-RKIP/PBP

中文名稱  磷脂酰乙醇胺結(jié)合蛋白1抗體品牌 

別    名 phosphatidylethanolamine-binding protein; PEBP; PEBP 1; PBP; Phosphatidylethanolamine-binding protein 1; PEBP-1; PEBP1; Prostatic-binding protein; Prostatic binding protein; Neuropolypeptide h3; HCNPpp; Raf kinase inhibitor protein; Hippocampal cholinergic neurostimulating peptide; HCNP.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 表觀遺傳學(xué)

蛋白分子量  predicted molecular weight: 21kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RKIP N-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

磷脂酰乙醇胺結(jié)合蛋白1抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.

HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. [SUBCELLULAR LOCATION] Cytoplasm. Belongs to the phosphatidylethanolamine-binding protein family.

Function : Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.

HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.

Subcellular Location : Cytoplasm.

Similarity : Belongs to the phosphatidylethanolamine-binding protein family.

信號傳導(dǎo)（Signaling Intermediates）

Raf激酶抑制蛋白(PKIP)屬于磷脂酰乙醇胺結(jié)合蛋白（phosphatidylethanolamine-binding protein, PEBP）家族,廣泛存在于各種不同的生物中,PKIP還參與了對NF-kB信號通路和G蛋白偶聯(lián)受體信號通路的調(diào)控,參與NF-κB信號通路的調(diào)控,參與了對細(xì)胞內(nèi)多種信號轉(zhuǎn)導(dǎo)通路的。RKIP在膜的生物合成、精子發(fā)生、神經(jīng)發(fā)育和細(xì)胞凋亡等生理過程中發(fā)揮重要作用，并參與了及等的病理過程。有學(xué)者認(rèn)為：RKIP有細(xì)胞轉(zhuǎn)移的作用。

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