腎胺酶抗體規(guī)格 英文名稱  Anti-Renalase

中文名稱  腎胺酶抗體規(guī)格 

別    名 C10orf59; Chromosome 10 open reading frame 59; FLJ11218; Hypothetical protein LOC55328; MAO C; Monoamine oxidase C; RENALASE; Renalase, FAD dependent amine oxidase; RNLS antibody; RNLS_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat, Dog, Pig, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領域    心 神經(jīng)生物學

蛋白分子量  predicted molecular weight: 36kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Renalase (191-230aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

腎胺酶抗體規(guī)格 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Renalase, a novel FAD dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and lowers systemic blood pressure. In vivo, it has been found to decrease cardiac contractility and heart rate and prevents a compensatory increase in peripheral vascular tone, possibly explaining the association between increased plasma catecholamines and heightened cardiovascular risk. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. The administration of renalase (or renalase mimics) may offer a new approach to the treatment of hypertension commonly found in renal disease, which is associated with a marked increase in cardiovascular disease.

Function : Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.

Subcellular Location : Secreted.

Tissue Specificity : Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.

Similarity : Belongs to the renalase family.

Database links : UniProtKB/Swiss-Prot: Q5VYX0.1

腎胺酶（renalase）是*產(chǎn)生一種新型的蛋白質，是一種依賴于黃素腺嘌呤二核苷酸的胺氧化酶,由*分泌入血,通過降解兒茶酚胺和。因*疾病與密切相關,因此研究腎胺酶的功能越來越受到人們的關注。

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★腎胺酶抗體規(guī)格 分子生物學：質粒抽提、PCR、Q-PCR、RT-PCR、分子生物學：基因合成、引物合成、基因測序、載體構建等

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