中文名稱(chēng)  鳥(niǎo)嘌呤核苷酸交換因子抗體品牌 

英文名稱(chēng)  Anti-RCBTB1/CLLD7

別    名 Chronic lymphocytic leukemia deletion region gene 7 protein; CLL deletion region gene 7 protein; CLLD7; CLLL7 protein; Guanine nucleotide exchange factor; broad-complex, tramtrack and bric a brac; Hypothetical protein FLJ39335; RCBT1_HUMAN; Rcbtb1; RCC1 and BTB domain-containing protein 1; Regulator of chromosome condensation and BTB domain-containing protein 1.

產(chǎn)品屬性：

鳥(niǎo)嘌呤核苷酸交換因子抗體品牌 濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類(lèi)型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

產(chǎn)品類(lèi)型   一抗  

研究領(lǐng)域     細(xì)胞生物 免疫學(xué) 表觀遺傳學(xué)

蛋白分子量  predicted molecular weight: 58kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RCBTB1/CLLD7

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

鳥(niǎo)嘌呤核苷酸交換因子抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The BTB domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. RCBTB1 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1), also known as GLP, CLLD7, CLLL7 or E4.5, is a 531 amino acid protein that localizes to the nucleus and contains two BTB (POZ) domains and six RCC1 repeats. Expressed ubiquitously, RCBTB1 is thought to be involved in cell cycle regulation, specifically via chromatin remodeling. The gene encoding RCBTB1 maps to a region on human chromosome 13 that is frequently deleted in B-cell chronic lymphocytic leukemia, suggesting a possible role for RCBTB1 in tumor suppression.

Function : May be involved in cell cycle regulation by chromatin remodeling.

Subcellular Location : Nucleus (Potential).

Tissue Specificity : Ubiquitously expressed

Similarity : Contains 2 BTB (POZ) domains.

Contains 6 RCC1 repeats.

Database links :

Entrez Gene: 785222 Cow

Entrez Gene: 55213 Human

Entrez Gene: 71330 Mouse

Entrez Gene: 361050 Rat

Omim: 607867 Human

SwissProt: Q8NDN9 Human

SwissProt: Q6NXM2 Mouse

Unigene: 508021 Human

Unigene: 234195 Mouse

Unigene: 229110 Rat

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★鳥(niǎo)嘌呤核苷酸交換因子抗體品牌 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測(cè)序、載體構(gòu)建等

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