技術(shù)外包服務:

★配對盒同源基因4抗體說明書 分子生物學：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動物蛋白表達系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細胞工程：細胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復、克隆形成)、細胞培養(yǎng)、細胞膜制備、穩(wěn)定細胞株構(gòu)建、細胞RNAi技術(shù)等等。

實驗流程：

配對盒同源基因4抗體說明書 英文名稱  Anti-PAX4

中文名稱  配對盒同源基因4抗體說明書 

別    名 KPD; MODY9; Paired box 4; Paired box gene 4; paired box homeotic gene 4; Paired box protein Pax-4; Paired domain gene 4; Pax4; PAX4_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat, Pig, Cow, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域    

蛋白分子量  predicted molecular weight: 39kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PAX4

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

配對盒同源基因4抗體說明書 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.

Involvement in disease; Defects in PAX4 are a cause of noninsulin-dependent diabetes mellitus (NIDDM) ; also known as diabetes mellitus type 2 or maturity-onset diabetes. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.

Genetic variations in PAX4 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM). IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.

Defects in PAX4 are a cause of susceptibility to diabetes mellitus ketosis-prone (KPD). KPD is an atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, as seen in classic type 1 diabetes, but after initiation of insulin therapy, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control. Metabolic studies show a markedly blunted insulin secretory response to glucose, partially reversible with the improvement of blood glucose control. Variable levels of insulin resistance are observed, especially in obese patients. Pancreatic beta-cell autoimmunity is a rare finding.

全、新、優(yōu)、品、好四大特點：

配對盒同源基因4抗體說明書 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標準品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團隊，產(chǎn)品一旦售出，實驗過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。

正在熱銷的相關(guān)產(chǎn)品：

Anti-Phospho-c-Fos (Thr232) /FITC 熒光素標記兔抗人、大、小鼠磷酸化c-fos抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-IL-23/FITC 熒光素標記白介素-23抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh CD133 antigen 造血干細胞抗原CD133抗體 規(guī)格 0.1ml

phospho-KLF5/Krueppel-like factor 5 (pSer272) 磷酸化腸道內(nèi)富含的Kruppel樣因子5抗原 0.5mg

IGSF12 英文名稱： 免疫球蛋白超家族成員12抗體 0.2ml

Rhesus antibody Rh SRF/SAP2/MCM1 生長激素釋放因子抗體(血清應答因子) 規(guī)格 0.2ml

Anti-IL-23/FITC 熒光素標記白介素-23抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-Protein C/FITC 熒光素標記APC活化蛋白C抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-Phospho-PLC gamma 2 (Tyr1217) /FITC 熒光素標記磷酸化磷酯酶Cγ2抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh COMMD7 銅代謝結(jié)構(gòu)域蛋白7抗體 規(guī)格 0.2ml

TTF-2(thyroid transcription factor 2;forkhead box E1) 甲狀腺轉(zhuǎn)錄因子-2(抗原) 0.5ml

JunB 英文名稱： 活化蛋白激酶B抗體 0.1ml

Rhesus antibody Rh Tubulin-alpha 微管蛋白α抗體 Tubulin α 規(guī)格 0.1ml

Anti-Phospho-PLC gamma 2 (Tyr1217) /FITC 熒光素標記磷酸化磷酯酶Cγ2抗體IgGMulti-class antibodies規(guī)格： 0.2ml

FAS/CD95(Mouse Factor-related Apoptosis) ELISA Kit 小鼠凋亡相關(guān)因子Multi-class antibodies規(guī)格： 48T

Anti-CAS/FITC 熒光素標記細胞凋亡敏感性基因抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh EMP2 上皮細胞膜蛋白2抗體 規(guī)格 0.1ml

大鼠c-jun ELISA Kit 大鼠c-jun ELISA Kit 96T

phospho-MEK5(Ser311+Thr315) 英文名稱： 磷酸化原活化蛋白激酶激酶5抗體 0.1ml

phospho-ATF2(Ser472) 英文名稱： 磷酸化活化復制因子2抗體 0.1ml

Anti-CAS/FITC 熒光素標記細胞凋亡敏感性基因抗體IgGMulti-class antibodies規(guī)格： 0.2ml

615小鼠株;Ca759

CD300A Others Mouse 小鼠 CD300A 人細胞裂解液 (陽性對照)

M14 人細胞

MDA-MB-468人癌細胞 Human breast cancer cell line MDA-MB-468 L-15+10%FBS

FAM3B Protein Human 重組人 FAM3B 蛋白 (Fc 標簽)

人胚皮膚成纖維細胞;CCC-ESF-1 人肺微內(nèi)皮細胞完全培養(yǎng)基 100mL

615小鼠株;Ca759

CD300A Others Mouse 小鼠 CD300A 人細胞裂解液 (陽性對照)

M14 人細胞

MDA-MB-468人癌細胞 Human breast cancer cell line MDA-MB-468 L-15+10%FBS

FAM3B Protein Human 重組人 FAM3B 蛋白 (Fc 標簽)

人胚皮膚成纖維細胞;CCC-ESF-1 人肺微內(nèi)皮細胞完全培養(yǎng)基 100mL

配對盒同源基因4抗體說明書 TNFRSF13C Others Rat 大鼠 BAFFR / TNFRSF13C 人細胞裂解液 (陽性對照)

小鼠星形膠質(zhì)細胞MA

人上皮細胞;MCF-10A

FD6細胞，人淋巴細胞與倉鼠肺細胞雜交細胞 小鼠,P19細胞 CM-H103胎兒真皮成纖維細胞完全培養(yǎng)基100mL

P3X63Ag8(小鼠細胞) 5×106cells/瓶×2

Promocell C-27437 Preadipocyte DiffereiationMedium KIT, 前脂肪細胞分化培養(yǎng)基套裝 500ml