雌激素受體共調(diào)節(jié)因子抗體品牌 英文名稱  Anti-Pescadillo

中文名稱  雌激素受體共調(diào)節(jié)因子抗體品牌 

別    名 FLJ43790; Homo sapiens pescadillo mRNA complete cds; PES 1; PES; pes1; PESC_HUMAN; Pescadillo (zebrafish) homolog 1 containing BRCT domain; Pescadillo homolog 1; Pescadillo homolog 1 containing BRCT domain (zebrafish); Pescadillo homolog; Pescadillo ribosomal biogenesis factor 1.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡

蛋白分子量  predicted molecular weight: 68kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Pescadillo

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

雌激素受體共調(diào)節(jié)因子抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Pescadillo may play a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression. The protein is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product.

Function : Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Subunit : Interacts with IRS1 and UBTF. May interact with MAP1B (By similarity). Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.

Subcellular Location : Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli (By similarity).

Post-translational modifications : Sumoylated.

Similarity : Belongs to the pescadillo family.

Contains 1 BRCT domain.

Database links : UniProtKB/Swiss-Prot: O00541.1

pescadillo基因是在研究逆轉(zhuǎn)錄誘發(fā)的斑馬魚胚胎發(fā)育缺陷中發(fā)現(xiàn)的,在不同物種中具有高度的保守性,PES1參與細(xì)胞周期,是核糖體生物合成所必需的因子,PES1突變或缺陷導(dǎo)致細(xì)胞周期阻滯該分子的表達(dá)受雌激素的誘導(dǎo);該分子主要分布于乳腺、卵巢、小腸等細(xì)胞分裂旺盛的組織;此外,在人、、、以及不同的細(xì)胞株中均發(fā)現(xiàn)Pescadillo的表達(dá),Pescadillo可能在的發(fā)生、發(fā)展中具有重要作用。

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