胎盤生長因子抗體費(fèi)用 英文名稱  Anti-PLGF

中文名稱  胎盤生長因子抗體費(fèi)用 

別    名 Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_HUMAN; Vascular endothelial growth factor related protein.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 免疫學(xué) 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 內(nèi)皮細(xì)胞

蛋白分子量  predicted molecular weight: 23kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PLGF C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

胎盤生長因子抗體費(fèi)用 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to the vascular endothelial growth factor. Alternative splicing of the PIGF primary transcript gives rise to two forms, named PIGF-1 and PIGF-2, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. The presence of the PIGF mRNA in thyroid, placenta, lung, and goiter has indicated the tissues where this factor functions. However, the role of PIGF in vascular development has not yet been clearly established.

Function : Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.

Subunit : Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is found both as homodimer and as monomer.

Subcellular Location : Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Post-translational modifications : N-glycosylated.

Similarity : Belongs to the PDGF/VEGF growth factor family.

Database links : UniProtKB/Swiss-Prot: P49763.2

PLGF胎盤生長因子是生長因子家族成員之一，是斑塊不穩(wěn)定的主要炎性激活物，因此它可作為ACS患者風(fēng)險(xiǎn)預(yù)測的生物學(xué)標(biāo)志物.尿胎盤生長因子水平可預(yù)測危險(xiǎn).研究人員發(fā)現(xiàn)，在疾病發(fā)作前的6到8周，患者尿液中的胎盤生長因子水平急劇下降,這種新的尿檢方法使提前1到2個(gè)月預(yù)測成為可能。亦有研究人員正在從事胎盤生長因子與，，等方面的研究。

相關(guān)抗體 bs-0280R(抗大鼠) bs-0234R(抗小鼠)

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