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顆粒蛋白前體抗體說明書 英文名稱  Anti-PGRN/Granulin

中文名稱  顆粒蛋白前體抗體說明書 

別    名 Granulin; Acrogranin; GEP; GP88; Granulin epithelin; GRN; PC cell derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G

產(chǎn)品類型   一抗  

研究領(lǐng)域     免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo)

蛋白分子量  predicted molecular weight: 63kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PGNR C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

顆粒蛋白前體抗體說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Function : Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.

Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Subcellular Location : Secreted.

Post-translational modifications : Granulins are disulfide bridged.

DISEASE : Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.

Similarity : Belongs to the granulin family.

1.PGRN目前主要。是65歲以下人群中第二種最常見的形式，該蛋白的多量產(chǎn)生，能夠損壞記憶和個性，而且還可能影響運動。這一發(fā)現(xiàn)也許可幫助解決關(guān)于該疾病病因的困惑： 癥(FTD)是常見的疾病，可見，除微管相關(guān)的tau蛋白導(dǎo)致癥外，又一個新的與癥有關(guān)蛋白又被科學(xué)家發(fā)現(xiàn)。

2.顆粒蛋白前體（PGRN）在。PGRN能過度增殖、以及促進組織新生，提示它可能是的一個非常重要的靶標(biāo)。

實驗流程：

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技術(shù)外包服務(wù):

★顆粒蛋白前體抗體說明書 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等

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