中文名稱  胰島素促進(jìn)因子抗體（胰十二指腸同源異型盒蛋白）品牌 

英文名稱  Anti-PDX1

別    名 PDX-1; pancreatic and duodenal homeobox 1; Insulin promoter factor 1; IPF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1; Insulin upstream factor 1; IUF-1; Glucose-sensitive factor; GSF

產(chǎn)品屬性：

胰島素促進(jìn)因子抗體（胰十二指腸同源異型盒蛋白）品牌 濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Pig

產(chǎn)品類型   一抗  

研究領(lǐng)域    細(xì)胞生物 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 病

蛋白分子量  predicted molecular weight: 30kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PDX1 C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

胰島素促進(jìn)因子抗體（胰十二指腸同源異型盒蛋白）品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Insulin promoter factor 1 is an islet-specific protein that activates transcription of the insulin andsomatostatin genes. It is a key regulator of islet peptide hormone expressionn and also plays an essential role in pancreatic development. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain. Subcellular Location: Nucleus. Tissue Specificity: Duodenum and pancreas.

Function : Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Subunit : Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7.

Subcellular Location : Nucleus.

Post-translational modifications : Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.

DISEASE : Defects in PDX1 are a cause of pancreatic agenesis (PAC)[MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant.

Defects in PDX1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.

Defects in PDX1 are the cause of maturity-onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Similarity : Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.

Contains 1 homeobox DNA-binding domain.

PDX1是一種同源框轉(zhuǎn)錄因子-即胰十二指腸同源異型盒基因，又稱IPF-1(胰島素促進(jìn)因子)、IDX-1、IUF-1。

近年來(lái)，科學(xué)家們對(duì)PDX1從不同的角度進(jìn)行了卓有成效的研究。有學(xué)者認(rèn)為；PDX1是*發(fā)育及胰島素基因轉(zhuǎn)錄表達(dá)的關(guān)鍵性轉(zhuǎn)錄因子，即決定于*前體細(xì)胞向B、A、D細(xì)胞的分化。

還有學(xué)者認(rèn)為：PDX1對(duì)于腸內(nèi)胚層背胰芽和腹胰芽的生長(zhǎng)、分化起重要作用，早期*表達(dá)的PDX-1對(duì)*上皮的形成和分化是必需的。

實(shí)驗(yàn)流程：

全、新、優(yōu)、品、好四大特點(diǎn)：

胰島素促進(jìn)因子抗體（胰十二指腸同源異型盒蛋白）品牌 全：公司提供上萬(wàn)種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊(duì)，產(chǎn)品一旦售出，實(shí)驗(yàn)過(guò)程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時(shí)沒(méi)有任何的后顧之憂。

技術(shù)外包服務(wù):

★胰島素促進(jìn)因子抗體（胰十二指腸同源異型盒蛋白）品牌 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測(cè)序、載體構(gòu)建等

★蛋白工程：原核、哺乳動(dòng)物蛋白表達(dá)系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細(xì)胞工程：細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。

正在熱銷的相關(guān)產(chǎn)品：

Anti-GLUR4/FITC 熒光素標(biāo)記谷氨酸受體4抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-OPN/FITC 熒光素標(biāo)記骨橋蛋白抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh BIN1 橋連整合因子蛋白抗體 規(guī)格 0.1ml

Endothelin-1 (ET-1) 內(nèi)皮素-1(抗原) 0.5mg

HSP105 英文名稱： 熱休克蛋白105抗體 0.1ml

Rhesus antibody Rh RBBP5 視網(wǎng)膜母細(xì)胞瘤結(jié)合蛋白5抗體 規(guī)格 0.2ml

Anti-OPN/FITC 熒光素標(biāo)記骨橋蛋白抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-LRRC4/FITC 熒光素標(biāo)記相關(guān)基因抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-Phospho-TAK1 (Thr184)/FITC 熒光素標(biāo)記磷酸化轉(zhuǎn)化生長(zhǎng)因子β活化激酶1抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh ADCY8 腺苷酸環(huán)化酶8抗體 規(guī)格 0.2ml

Rabbit Anti-dog IgG/APC APC標(biāo)記的兔抗狗IgG 0.1ml

GEFT 英文名稱： 鳥(niǎo)嘌呤核苷酸交換因子GEFT抗體 0.2ml

Rhesus antibody Rh Rabbit anti-chicken IgM whole serum 兔抗雞IgM抗血清 規(guī)格 1ml

Anti-Phospho-TAK1 (Thr184)/FITC 熒光素標(biāo)記磷酸化轉(zhuǎn)化生長(zhǎng)因子β活化激酶1抗體IgGMulti-class antibodies規(guī)格： 0.2ml

HSP-20(Human Heat Shock Protein 20) ELISA Kit 人熱休克蛋白20Multi-class antibodies規(guī)格： 48T

Anti-PADI4 相關(guān)基因抗體Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh HPV33 E6 人類狀瘤病毒33抗體 規(guī)格 0.2ml

LTB4 ELISA Kit 大鼠白三烯B4 96T

Phospho-PDK1(Ser241) 英文名稱： 磷酸化3磷酸肌醇依賴性蛋白激酶1 0.1ml

CAPH 英文名稱： 染色體相關(guān)蛋白H抗體 0.2ml

Anti-PADI4 相關(guān)基因抗體Multi-class antibodies規(guī)格： 0.1ml

CL-0296MX-1(人癌細(xì)胞)5×106cells/瓶×2

MBL1 Others Rat 大鼠 MBL1 人細(xì)胞裂解液 (陽(yáng)性對(duì)照)

成纖維細(xì)胞cDNAHMF cDNA

HBL-100細(xì)胞，人細(xì)胞 兔腎細(xì)胞系,RK-13細(xì)胞 細(xì)胞Many types of cells包裝：5 × 105次方(1ml)

SW1116(人腺癌細(xì)胞) 5×106cells/瓶×2

HSaVEC Pellet 人隱內(nèi)皮細(xì)胞團(tuán)塊 > 1 mio.cells 間充質(zhì)干細(xì)胞脂肪細(xì)胞分化生長(zhǎng)添加物MADS

CL-0294MuM-2C(人眼脈絡(luò)細(xì)胞)5×106cells/瓶×2

CHL1 Others Mouse 小鼠 CHL-1 人細(xì)胞裂解液 (陽(yáng)性對(duì)照)

人肺間充質(zhì)干細(xì)胞cDNAHPMSC cDNA

豬源細(xì)胞 皮膚細(xì)胞，CCD-1095Sk細(xì)胞 ZM755細(xì)胞，615小鼠滑膜瘤株

人APP-PS1雙基因轉(zhuǎn)染細(xì)胞株(HEK293);APP-PS1

HA Others H5N2 甲型 H5N2 血凝素HA1 (Hemagglutinin) 人細(xì)胞裂解液 (陽(yáng)性對(duì)照)

胰島素促進(jìn)因子抗體（胰十二指腸同源異型盒蛋白）品牌 FCGRT & B2M Others Mouse 小鼠 FCGRT & B2M Heterodimer 人細(xì)胞裂解液 (陽(yáng)性對(duì)照)

C6, 大鼠腦細(xì)胞

大鼠腦內(nèi)皮細(xì)胞完全培養(yǎng)基 100mL

LLC-PK1豬腎近曲小管上皮細(xì)胞 LLC-PK1 porcine kidney proximal tubular epithelial cells M199+3% FBS/DMEM+F12+12%FBS

IFNB1 Protein Mouse 重組小鼠 IFNB1 / IFN-beta / Ierferon beta 蛋白 (Fc 標(biāo)簽)

MDA-MB-468-06(人癌細(xì)胞) 5×106cells/瓶×2 Y1(腎上腺皮質(zhì)細(xì)胞)