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肽聚糖識別蛋白1抗體品牌 英文名稱  Anti-PGRPS

中文名稱  肽聚糖識別蛋白1抗體品牌 

別    名 Peptidoglycan recognition protein 1; Peptidoglycan recognition protein; PGLYRP; PGLYRP1; PGRP; PGRP S; PGRP-PEN; PGRP-S; TAG7; TNFSF 3L; TNFSF3L; PGRP1_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域    細(xì)胞生物 微生物學(xué) 神經(jīng)生物學(xué) 細(xì)胞凋亡 細(xì)菌及 糖蛋白

蛋白分子量  predicted molecular weight: 19kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PGRPS

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

肽聚糖識別蛋白1抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRPS, PGRPIA, and PGRP-I-beta) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRPS is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRPS may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50–100 times higher than in neutrophils.

Function : Pattern receptor that binds to murein peptidoglycans(PGN) of Gram-positive bacteria. Has bactericidal activity towardsGram-positive bacteria. May kill Gram-positive bacteria byinterfering with peptidoglycan biosynthesis. Binds also toGram-negative bacteria, and has bacteriostatic activity towardsGram-negative bacteria. Plays a role in innate immunity.

Subunit : Homodimer; disulfide-linked.

Subcellular Location : Secreted. Cytoplasmic granule (Bysimilarity).

Post-translational modifications : N-glycosylated. N-glycosylation is required for bactericidalactivity.

Similarity : Belongs to the N-acetylmuramoyl-L-alanine amidase 2family.

Database links : UniProtKB/Swiss-Prot: O75594.1

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