脂滴包被蛋白A+B抗體品牌 英文名稱  Anti-Perilipin A+B

中文名稱  脂滴包被蛋白A+B抗體品牌 

別    名 Lipid droplet associated protein; PERIA; PERIB; Perilipin A; Perilipin; Perilipin B; PerilipinA; PerilipinB; PLIN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Chicken, SheepDog

產(chǎn)品類型   一抗  

研究領域     心 細胞生物 信號轉導

蛋白分子量  predicted molecular weight: 54-56kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Perilipin A+B

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

脂滴包被蛋白A+B抗體品牌 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, perilipin is phosphorylated by protein kinase A. Once activated, perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.

Function : Perilipin A: Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness.

Perilipin B: May be involved in development and maintenance of adipose tissue.

Subunit : Perilipin A: Interacts with ABHD5.

Perilipin B: Membrane; Peripheral membrane protein.

Tissue Specificity : Perilipin A: Adipocytes.

Perilipin B: Milk lipid globules.

Post-translational modifications : Perilipin A: Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.

Perilipin B: Acylated; primarily with C14, C16 and C18 fatty acids.

DISEASE : Perilipin A: Defects in PLIN1 are the cause of familial partial lipodystrophy type 4 (FPLD4) [MIM:613877]. FPLD4 is a form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.

Perilipin B:

Similarity : Perilipin A: Belongs to the perilipin family.

Perilipin B: Belongs to the perilipin family.

Database links : UniProtKB/Swiss-Prot: O60240.2

UniProtKB/Swiss-Prot: Q99541.2

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