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神經叢蛋白A1抗體說明書 英文名稱  Anti-Plexin A1

中文名稱  神經叢蛋白A1抗體說明書 

別    名 NOV; NOV/plexin A1 protein; NOVP; Plexin1; PlexinA1; PLXN1; PLXNA1; PLXNA1; protein; Semaphorin receptor NOV.

產品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig

產品類型   一抗  

研究領域    心 細胞生物 免疫學 發(fā)育生物學 神經生物學 細胞膜受體

蛋白分子量  predicted molecular weight: 200kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Plexin A1 (926-974aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

神經叢蛋白A1抗體說明書 產品應用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產品介紹 Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury.

Subcellular Location : Membrane; Single-pass type I membrane protein.

Tissue Specificity : Detected in fetal brain, lung, liver and kidney.

Similarity : Belongs to the plexin family.

Contains 1 Sema domain.

Plexins是一種單途徑、具有多向潛在功能的跨膜蛋白，為Sema-phorins（神經信號蛋白）家族的受體,PlexinA1蛋白主要定位于細胞質和細胞膜，Semaphorins的很多重要的生理作用均是通過Plexins信號傳導來發(fā)揮作用的。PlexinA1在形成、心生成、胚胎發(fā)生和免疫反應等方面發(fā)揮重要作用。

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