配對盒基因9抗體說明書 英文名稱  Anti-PAX9

中文名稱  配對盒基因9抗體說明書 

別    名 Paired box 9; Paired box gene 9; Paired box homeotic gene 9; Paired box protein 9; Paired box protein Pax 9; Paired box protein Pax9; Paired domain gene 9; PAX 9; PAX9_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat

產(chǎn)品類型   一抗  

研究領(lǐng)域     信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子

蛋白分子量  predicted molecular weight: 36kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PAX9 C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

配對盒基因9抗體說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 PAX9 is a member of the paired box (PAX) family of transcription factors. Proteins in this family typically contain a paired box domain, a paired type homeodomain and an octapeptide sequence. They are important during fetal development and have also been implicated in cancer growth.

The exact role of PAX9 is unclear, but it is thought to be involved in development of various organs, skeletal tissue and stratified squamous epithelia. Mutations in PAX9 have also been implicated in oligodontia, a type of tooth agenesis which is a common developmental anomoly in humans.

Function : Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity).

Subunit : Interacts with KDM5B.

DISEASE : ooth agenesis selective 3 (STHAG3) [MIM:604625]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity : Contains 1 paired domain.

Database links : UniProtKB/Swiss-Prot: P55771.3

同源結(jié)構(gòu)域蛋白（Homeodomain Proteins）

PAX9屬于轉(zhuǎn)錄抑制因子PAXs的一種。在胚胎發(fā)育和中起關(guān)鍵作用。其突變和某些的有關(guān)。<

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