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B淋巴細胞受體相關(guān)蛋白抗體說明書 英文名稱  Anti-PHB2/REA/Prohibitin 2

中文名稱  B淋巴細胞受體相關(guān)蛋白抗體說明書 

別    名 B cell receptor associated protein BAP37; B-cell associated protein; B-cell receptor-associated protein BAP37; Bap 37; BAP; Bap37; BCAP 37; BCAP37; D prohibitin; D-prohibitin; MGC117268; p22; PHB 2; PHB2; PHB2_HUMAN; PNAS 141; PNAS141; Prohibitin 2; Prohibitin-2; Prohibitin2; Repressor of Estrogen Receptor Activity.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse

產(chǎn)品類型   一抗  

研究領(lǐng)域    信號轉(zhuǎn)導 細胞凋亡 生長因子和激素 淋巴細胞 b-淋巴細胞 表觀遺傳學

蛋白分子量  predicted molecular weight: 33kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Prohibitin 2

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

B淋巴細胞受體相關(guān)蛋白抗體說明書 產(chǎn)品應用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in nuclear and mitochondrial compartments in eukaryotic cells and exert multiple cellular functions (1). PHB2 (REA) was originally identified as an estrogen receptor (ER) specific coregulator. It directly interacts with hormone-bound ER and represses its transcriptional activity by competitive inhibition of SRC-1 coactivation of ER (2,3). Together with COUP-TFs, PHB2 also interacts with histone deacetylases HDAC1 and HDAC5, and mediates transcriptional regulation by ER through coupling the deacetylase to the transcription activation complex (4). Another important function of PHB2 is stablization of mitochondrial proteins. PHB1/PHB2 hetrodimers form large ring complexes on the mitochondrial membrane (5), acting as chaperones to stablize important mitochodrial proteins, such as OPA1 and Hax1 to support mitochondrial morphogenesis and protection against apoptosis (6-8).

Function : Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Subunit : Interacts with PHB, ESR1, HDAC1 and HDAC5. Interacts with ZNF703.

Subcellular Location : Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear.

實驗流程：

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