中文名稱  橋粒斑菲素蛋白2抗體說(shuō)明書 

英文名稱  Anti-Plakophilin 2

別    名 ARVD 9; ARVD-9; ARVD9; PKP 2; PKP2; PKP-2; Plakophilin-2. Plakophilin2; PKP2_HUMAN.

產(chǎn)品屬性：

橋粒斑菲素蛋白2抗體說(shuō)明書 濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

產(chǎn)品類型   一抗  

研究領(lǐng)域    心 神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞骨架

蛋白分子量  predicted molecular weight: 97kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Plakophilin 2

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

橋粒斑菲素蛋白2抗體說(shuō)明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains, and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin-1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration. Plakophilin-2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin-3 plays a role in both desmosome-dependent adhesion and signaling pathways. Plakophilin-4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.

Function : May play a role in junctional plaques.

Subunit : Interacts with DSC2.

Subcellular Location : Nucleus. Cell junction, desmosome.Note=Nuclear and associated with desmosomes.

Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE : Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9) [MIM:609040]; also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.

Similarity : Belongs to the beta-catenin family.

Contains 8 ARM repeats.

Database links : UniProtKB/Swiss-Prot: Q99959.2

實(shí)驗(yàn)流程：

全、新、優(yōu)、品、好四大特點(diǎn)：

橋粒斑菲素蛋白2抗體說(shuō)明書 全：公司提供上萬(wàn)種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊(duì)，產(chǎn)品一旦售出，實(shí)驗(yàn)過(guò)程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時(shí)沒(méi)有任何的后顧之憂。

技術(shù)外包服務(wù):

★橋粒斑菲素蛋白2抗體說(shuō)明書 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測(cè)序、載體構(gòu)建等

★蛋白工程：原核、哺乳動(dòng)物蛋白表達(dá)系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細(xì)胞工程：細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。

正在熱銷的相關(guān)產(chǎn)品：

EK(Human epidermal keratin) ELISA Kit 人表皮角蛋白Multi-class antibodies規(guī)格： 48T

Anti-Phospho-HER3 (Tyr1197) 磷酸化HER3受體抗體Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh MIC1/C18orf8 相關(guān)蛋白MIC1抗體 規(guī)格 0.2ml

KLK 8(Human urokinase-type plasminogen activator) ELISA Kit 人激肽釋放酶8 96T

RNF158 英文名稱： 蛋酸酶1結(jié)合蛋白/環(huán)指蛋白158抗體 0.2ml

CEP95 英文名稱： 中心體蛋白95抗體 0.1ml

Anti-Phospho-HER3 (Tyr1197) 磷酸化HER3受體抗體Multi-class antibodies規(guī)格： 0.1ml

Anti-NR2B/NMDAR2B /FITC 熒光素標(biāo)記谷氨酸受體2B抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-CEA/Gold 膠體金離子標(biāo)記鼠抗人癌胚抗原單克隆抗體(包被)IgGMulti-class antibodies規(guī)格： 0.2ml

單核-巨噬細(xì)胞基質(zhì)金屬蛋白酶抗體 Anti-CD147/EMMPRIN 0.1ml

Goat Anti-rat IgG/FITC FITC標(biāo)記的羊抗大鼠IgG 0.3ml

FNDC5 英文名稱： Ⅲ型纖維連接蛋白域蛋白2/5抗體 0.2ml

Rhesus antibody Rh PMCA4/Calcium Pump PMCA4 ATPase 細(xì)胞膜鈣ATP酶4抗體 規(guī)格 0.2ml

Anti-CEA/Gold 膠體金離子標(biāo)記鼠抗人癌胚抗原單克隆抗體(包被)IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-IL-16/FITC 熒光素標(biāo)記白細(xì)胞介素-16抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-CD150/SLAM/FITC 熒光素標(biāo)記CD150抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh APG4B/AUTL1 自噬相關(guān)蛋白4B抗體 規(guī)格 0.2ml

Rabbit Anti-rat IgG/HRP 辣根過(guò)氧化物酶標(biāo)記的兔抗大鼠IgG 0.1ml

GGCX 英文名稱： γ-谷酰羧化酶抗體 0.2ml

Rhesus antibody Rh Rabbit Anti-human sIgA/Alexa Fluor 488 Alexa Fluor 488標(biāo)記的兔抗人分泌型IgA 規(guī)格 0.1ml

Anti-CD150/SLAM/FITC 熒光素標(biāo)記CD150抗體IgGMulti-class antibodies規(guī)格： 0.2ml

大鼠巨噬細(xì)胞炎性蛋白2(MIP-2)ELISA試劑盒 ，英文名： MIP-2 ELISA Kit

人酸性成纖維細(xì)胞生長(zhǎng)因子1(aFGF-1)ELISA檢測(cè)試劑盒Humanacidicfibroblastgrowthfactor1,aFGF-1ELISAKit 96T/48T

病毒(CSFV)核酸檢測(cè)試劑盒(-PCR法) 48T

CLIAKitforNHE3(HumanNa+/H+exchanger3)ELISAKit人Na+/H+交換體3規(guī)格：48T/96T

體液CMV(CYTOMEGALOVIRUS)病毒定性檢測(cè)試劑盒20次

ELISAKitLAT人T細(xì)胞活化連接蛋白規(guī)格：48T/96T

大鼠白介素1α(IL-1α)ELISA 試劑盒 96T/48T 試劑盒 組裝/原裝

人抗體IgG(JE IgG)免疫試劑盒 Human Japanese Encephalitis Aibody(IgG)ELISA Kit

PlaVitaminB12,VB12ELISAKit植物維生素B12(VB12)ELISA試劑盒規(guī)格：96T/48T

石蠟切片組織PI-3KINASEP110BETA蛋白表達(dá)NBT顯色光學(xué)顯微鏡檢測(cè)試劑盒10/20次

HumaeceptorⅡfoheFcregionofimmunoglobulinG,FcγRⅡELISA試劑盒人免疫球蛋白GFc段受體Ⅱ(FcγRⅡ/CD32)ELISA試劑盒規(guī)格：96T/48T

HumanypsinELISAKit人胰蛋白酶(ypsin)ELISA試劑盒規(guī)格：96T/48T

橋粒斑菲素蛋白2抗體說(shuō)明書 大鼠補(bǔ)體因子H(CFH)ELISA 試劑盒 96T/48T 試劑盒 組裝/原裝

人免疫球蛋白D(IgD)免疫試劑盒 human Immunoglobulin D,IgD ELISA Kit

MouseVascuoarendothelialcellgrowthfactorreceptor2,VEGFR-2/Flk-1ELISAKit小鼠內(nèi)皮細(xì)胞生長(zhǎng)因子受體2(VEGFR-2/Flk-1)ELISA試劑盒規(guī)格：96T/48T

石蠟切片組織CASPASE-4蛋白表達(dá)NBT顯色光學(xué)顯微鏡檢測(cè)試劑盒10/20次

HumanProstaglandinF2α,PGF2αELISA試劑盒人素F2α(PGF2α)ELISA試劑盒規(guī)格：96T/48T

Humahymosinα1ELISAKit人胸腺肽α1(Thymosinα1)ELISA試劑盒規(guī)格：96T/48T